دورية أكاديمية
Urinary N-Terminal Pro-Brain Natriuretic Peptide Predicts Acute Kidney Injury and Severe Disease in COVID-19
| العنوان: | Urinary N-Terminal Pro-Brain Natriuretic Peptide Predicts Acute Kidney Injury and Severe Disease in COVID-19 |
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| المؤلفون: | Vogel, Manuel Julian, Leininger, Simon B, Staudner, Stephan T, Hubauer, Ute, Wallner, Stefan, Mustroph, Julian, Hanses, Frank, Zimmermann, Markus, Lehn, Petra, Burkhardt, Ralph, Maier, Lars S, Hupf, Julian, Jungbauer, Carsten G |
| المصدر: | Kidney and Blood Pressure Research ; volume 48, issue 1, page 424-435 ; ISSN 1420-4096 1423-0143 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, Nephrology |
| الوصف: | Introduction: The ongoing COVID-19 pandemic is placing an extraordinary burden on our health care system with its limited resources. Accurate triage of patients is necessary to ensure medical care for those most severely affected. In this regard, biomarkers could contribute to risk evaluation. The aim of this prospective observational clinical study was to assess the relationship between urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) and acute kidney injury (AKI) as well as severe disease in patients with COVID-19. Methods: 125 patients treated with an acute respiratory infection in the emergency department of the University Hospital Regensburg were analyzed. These patients were divided into a COVID-19 cohort ( n = 91) and a cohort with infections not caused by severe acute respiratory syndrome-coronavirus-2 ( n = 34). NT-proBNP was determined from serum and fresh urine samples collected in the emergency department. Clinical endpoints were the development of AKI and a composite one consisting of AKI, intensive care unit admission, and in-hospital death. Results: 11 (12.1%) COVID-19 patients developed AKI during hospitalization, whereas 15 (16.5%) reached the composite endpoint. Urinary NT-proBNP was significantly elevated in COVID-19 patients who suffered AKI or reached the composite endpoint (each p < 0.005). In a multivariate regression analysis adjusted for age, chronic kidney disease, chronic heart failure, and arterial hypertension, urinary NT-proBNP was identified as independent predictor of AKI ( p = 0.017, OR = 3.91 [CI: 1.28–11.97] per standard deviation [SD]), as well as of the composite endpoint ( p = 0.026, OR 2.66 [CI: 1.13–6.28] per SD). Conclusion: Urinary NT-proBNP might help identify patients at risk for AKI and severe disease progression in COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000529690 |
| الإتاحة: | https://doi.org/10.1159/000529690Test https://karger.com/kbr/article-pdf/48/1/424/4113479/000529690.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.E34533CF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000529690 |
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