Hypergastrinemia as a Cause of Chromogranin A Increase in Blood in Patients Suspected to Have Neuroendocrine Tumor
| العنوان: | Hypergastrinemia as a Cause of Chromogranin A Increase in Blood in Patients Suspected to Have Neuroendocrine Tumor |
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| المؤلفون: | Helge L. Waldum, Ola Kleveland, Unni Syversen, Kari Slørdahl |
| المصدر: | Digestion. 64:71-74 |
| بيانات النشر: | S. Karger AG, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Gastritis, Atrophic, endocrine system, medicine.medical_specialty, Enterochromaffin-like Cells, Radioimmunoassay, Peptide hormone, digestive system, Gastroenterology, Immunoenzyme Techniques, Stomach Neoplasms, Pepsinogen A, Internal medicine, Gastrins, Biomarkers, Tumor, Chromogranins, medicine, Humans, Enterochromaffin-like cell, Tumor marker, Gastrin, Hyperplasia, biology, business.industry, Stomach, Chromogranin A, medicine.disease, Neuroendocrine Tumors, Endocrinology, Gastrointestinal hormone, Gastric Mucosa, Gastrinoma, biology.protein, Gastritis, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Background: Chromogranin A (CgA) is a sensitive marker for neuroendocrine neoplasia. Enterochromaffin-like cell hyperplasia secondary to hypergastrinemia also leads to CgA increase in blood. Treatment with inhibitors of acid secretion, atrophic gastritis and infection with Helicobacter pylori are prevalent conditions leading to hypergastrinemia. We therefore wanted to study whether concomitant determination of gastrin could increase the utility of CgA as a marker of neuroendocrine neoplasia. Methods: CgA and gastrin concentrations were determined by radioimmunoassay methods, while pepsinogen I (used to diagnose severe atrophic gastritis) was determined by a commercial immunoenzymatic assay. Results: Among 100 patients with elevated CgA, we found that 29% had hypergastrinemia. Vice versa, CgA was elevated in 23 out of 26 (88.5%) in a population of patients with hypergastrinemia. By determining pepsinogen I in blood in patients with hypergastrinemia, a proportion of them was diagnosed as having severe atrophic gastritis. Conclusion: We conclude that determination of gastrin in blood in patients with CgA elevation will increase the utility of CgA in the diagnosis of neuroendocrine tumors. |
| تدمد: | 1421-9867 0012-2823 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dae2f6a6df4fdcc0f53d5a65314a37Test https://doi.org/10.1159/000048842Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....18dae2f6a6df4fdcc0f53d5a65314a37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219867 00122823 |
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