دورية أكاديمية
Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
| العنوان: | Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells |
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| المؤلفون: | Colli, Maikel L., Paula, Flavia M., Marselli, Lorella, Marchetti, Piero, Roivainen, Merja, Eizirik, Decio L., Op de beeck, Anne |
| المصدر: | Journal of Innate Immunity ; volume 11, issue 4, page 375-390 ; ISSN 1662-811X 1662-8128 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2019 |
| الوصف: | Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive pancreatic β cell destruction. The disease is triggered by a combination of genetic and environmental factors, but the mechanisms leading to the triggering of early innate and late adaptive immunity and consequent progressive pancreatic β cell death remain unclear. The insulin-producing β cells are active secretory cells and are thus particularly sensitive to endoplasmic reticulum (ER) stress. ER stress plays an important role in the pathologic pathway leading to autoimmunity, islet inflammation, and β cell death. We show here that group B coxsackievirus (CVB) infection, a putative causative factor for T1D, induces a partial ER stress in rat and human β cells. The activation of the PERK/ATF4/CHOP branch is blunted while the IRE1α branch leads to increased spliced XBP1 expression and c-Jun N-terminal kinase (JNK) activation. Interestingly, JNK1 activation is essential for CVB amplification in both human and rat β cells. Furthermore, a chemically induced ER stress preceding viral infection increases viral replication, in a process dependent on IRE1α activation. Our findings show that CVB tailors the unfolded protein response in β cells to support their replication, preferentially triggering the pro-viral IRE1α/XBP1s/JNK1 pathway while blocking the pro-apoptotic PERK/ATF4/CHOP pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000496034 |
| الإتاحة: | https://doi.org/10.1159/000496034Test https://www.karger.com/Article/Pdf/496034Test |
| حقوق: | https://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.FEA5910C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000496034 |
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