Frequent Occurrence of IgE and lgG4 Antibodies against Saliva of Aedes communis and Aedes aegypti Mosquitoes in Children
| العنوان: | Frequent Occurrence of IgE and lgG4 Antibodies against Saliva of Aedes communis and Aedes aegypti Mosquitoes in Children |
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| المؤلفون: | R. Ruiz-Maldonado, Guido François, Timo Reunala, Kati Palosuo, Timo Palosuo, M. Miyanij, H. Brummer-Korvenkontio, A. Löve |
| المصدر: | International Archives of Allergy and Immunology. 104:366-371 |
| بيانات النشر: | S. Karger AG, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Aedes, 0303 health sciences, Saliva, biology, fungi, 030231 tropical medicine, Immunology, General Medicine, Aedes aegypti, biology.organism_classification, Immunoglobulin E, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, parasitic diseases, Humoral immunity, biology.protein, Immunology and Allergy, Antibody, 030304 developmental biology |
| الوصف: | We examined the prevalence of IgE and IgG4 class antibodies to the saliva of Aedes communis and Aedes aegypti mosquitoes in the sera of three groups of exposed children using a sensitive immunoblot method. The frequencies of IgE antibodies to the major 36-kD A. communis and A. aegypti saliva antigens ranged from 82 to 90% in the 20 Finnish, 17 Kenyan, and 20 Mexican children. The corresponding IgG4 antibody frequencies were 85, 41, and 20%, respectively. The nonexposed 20 Icelandic children did not show IgE or IgG4 antisaliva antibodies. Several of the Finish children showed also IgE and IgG4 antibodies to a 22-kD A. communis saliva antigen. The Finnish children abnormally sensitive to mosquito bites had frequently IgE and IgG4 antibodies to the 22-kD A. communis saliva antigen, suggesting that these antibodies play a role in the pathogenesis of immediate cutaneous mosquito bite reactions. In contrast to this, no increase was found in the A aegypti antibody frequencies in the Kenyan and Mexican children with papular urticaria, suggesting that humoral immune response to A. aegypti saliva is not involved in the development of this disorder. The present results show that humoral IgE and IgG4 immune responses to Aedes mosquito saliva antigens is common in children living both in temperature and tropical zones. The IgE antibodies seem to be involved in the immediate mosquito bite wheal-ing, and the occurrence of the IgG4 subclass antisaliva antibodies might be an indicator of intense mosquito bite exposure. |
| تدمد: | 1423-0097 1018-2438 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::df9825248874ffede9b361d3b4a1f34cTest https://doi.org/10.1159/000236693Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........df9825248874ffede9b361d3b4a1f34c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
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