Targeted Treatment of Esophagogastric Cancer
| العنوان: | Targeted Treatment of Esophagogastric Cancer |
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| المؤلفون: | Ralf-Dieter Hofheinz, Hans-Georg Kopp |
| المصدر: | Oncology Research and Treatment. 39:788-794 |
| بيانات النشر: | S. Karger AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Antineoplastic Agents, HER2/neu, Ramucirumab, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Stomach Neoplasms, Trastuzumab, Internal medicine, medicine, Humans, Molecular Targeted Therapy, Chemotherapy, Evidence-Based Medicine, biology, business.industry, Stomach, Antibodies, Monoclonal, Hematology, Esophageal cancer, medicine.disease, Neoplasm Proteins, Treatment Outcome, 030104 developmental biology, medicine.anatomical_structure, Paclitaxel, chemistry, 030220 oncology & carcinogenesis, biology.protein, Adenocarcinoma, Esophagogastric Junction, business, medicine.drug |
| الوصف: | Adenocarcinoma of the esophagogastric junction (EGJ) and stomach remains one of the most common causes of cancer-related death worldwide. Although there is increasing data on the mutational landscape of esophagogastric cancer, phase III trials often yield negative results, and there is a paucity of approved targeted agents. For the time being, the subset of patients carrying HER2-positive metastatic tumors can receive trastuzumab in addition to chemotherapy. Furthermore, ramucirumab has been found to be active both as a single agent and in combination with paclitaxel. Herein, we give an overview of currently approved targeted treatments for locally advanced/resectable as well as unresectable/metastatic EGJ/gastric adenocarcinoma, summarizing the underlying clinical studies. Moreover, further potential targets still under investigation are presented. |
| تدمد: | 2296-5262 2296-5270 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e1159140ffb4159b30a9e6475c92aaTest https://doi.org/10.1159/000452877Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b9e1159140ffb4159b30a9e6475c92aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22965262 22965270 |
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