The Rationale for in utero Repair of Myelomeningocele
| العنوان: | The Rationale for in utero Repair of Myelomeningocele |
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| المؤلفون: | Mark P. Johnson, N S Adzick, Danielle S. Walsh, Leslie N. Sutton |
| المصدر: | Fetal Diagnosis and Therapy. 16:312-322 |
| بيانات النشر: | S. Karger AG, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Postnatal Care, Embryology, medicine.medical_specialty, Meningomyelocele, Obstetric Surgical Procedures, Prenatal diagnosis, Abortion, Central nervous system disease, Pregnancy, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Fetus, business.industry, Obstetrics and Gynecology, General Medicine, medicine.disease, Spinal cord, Surgery, Disease Models, Animal, Fetal Diseases, medicine.anatomical_structure, Spinal Cord, In utero, embryonic structures, Pediatrics, Perinatology and Child Health, Female, business |
| الوصف: | Objectives: Despite advances in prenatal diagnosis, management of fetal myelomeningocele has been limited to abortion or supportive postnatal care. The rationale for fetal repair of myelomeningocele and initial clinical outcomes are discussed. Methods: A complete review of the literature concerning fetal myelomeningocele and repair was performed. Results: While myelomeningocele is a primary embryologic disorder, neurologic damage is also secondary to progressive in utero damage to the exposed spinal cord. Animal models with midgestational coverage of the spinal defect demonstrate near normal neurologic function at term. Early clinical results suggest that fetal closure can salvage neurologic function, reverse hindbrain herniation, and diminish the need for ventriculoperitoneal shunting. Conclusions: In utero repair of myelomeningocele may improve neurologic outcomes and reduce hindbrain herniation in selected patients. |
| تدمد: | 1421-9964 1015-3837 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60011d31b4f89db712fd1380619a0d4eTest https://doi.org/10.1159/000053934Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....60011d31b4f89db712fd1380619a0d4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219964 10153837 |
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