Augmentation of Antipsychotics with Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Patients with Dominant Negative Symptoms: A Pilot Study of Effectiveness
| العنوان: | Augmentation of Antipsychotics with Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Patients with Dominant Negative Symptoms: A Pilot Study of Effectiveness |
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| المؤلفون: | Emilia Kołodziej-Kowalska, Agnieszka Pawełczyk, Tomasz Pawełczyk, Jolanta Rabe-Jabłońska |
| المصدر: | Neuropsychobiology. 70:158-164 |
| بيانات النشر: | S. Karger AG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Combination therapy, medicine.medical_treatment, Dominant negative, Pilot Projects, Severity of Illness Index, behavioral disciplines and activities, Young Adult, Electroconvulsive therapy, Internal medicine, mental disorders, Severity of illness, medicine, Humans, Young adult, Electroconvulsive Therapy, Psychiatry, Biological Psychiatry, Positive and Negative Syndrome Scale, business.industry, Middle Aged, medicine.disease, Combined Modality Therapy, Psychiatry and Mental health, Treatment Outcome, Neuropsychology and Physiological Psychology, Schizophrenia, Clinical Global Impression, Female, business, Antipsychotic Agents |
| الوصف: | Objectives: The aim of the study was to determine the effectiveness of the augmentation of antipsychotics (AP) with electroconvulsive therapy (ECT) in treatment-resistant schizophrenia (TRS) patients with dominant negative symptoms. Methods: The study encompassed 34 patients aged 21-55 years, 47.1% of whom were female, who were diagnosed with TRS. Each patient underwent a course of ECT sessions combined with AP medications which had previously been found to be ineffective. Prior to ECT and within 3 days after the final ECT session, the participants were evaluated on the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia and the Clinical Global Impression scales. Results: Augmentation of AP therapy with ECT led to a significant decrease in symptom severity in TRS patients with dominant negative symptoms, 58.8% of whom demonstrated at least a 25% decrease in the total PANSS score. The greatest reductions were observed in the general and positive PANSS subscales (mean ± SD: 11.35 ± 7.43 and 6.79 ± 5.23 patients), and the least significant in the negative symptoms subscale (5.03 ± 4.36 patients). Conclusion: Augmentation of AP therapy with ECT in a group of TRS patients with dominant negative symptoms induced a significant decrease in symptom severity. The greatest reductions were obtained in general and positive symptoms and the least in negative symptoms. |
| تدمد: | 1423-0224 0302-282X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83388041d2435794e27b40d5ecffc34aTest https://doi.org/10.1159/000366484Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....83388041d2435794e27b40d5ecffc34a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230224 0302282X |
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