Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent
| العنوان: | Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent |
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| المؤلفون: | Chang Seok Lee, Il-Hong Bae, Jeong Ah Hwang, Eun-Soo Lee, Dae Yong Kim, Seong Geun Oh, John Hwan Lee, Ho Sik Rho, Nok Hyun Park, Se Hwa Kim, Yong Jin Kim |
| المصدر: | Skin Pharmacology and Physiology. 30:190-196 |
| بيانات النشر: | S. Karger AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Cell Survival, Physiology, Skin Lightening Preparations, Melanoma, Experimental, Human skin, Dermatology, Biology, Cell Line, Melanin, Mice, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Equivalent, Hyperpigmentation, Cell Line, Tumor, medicine, Animals, Humans, Thymol, Cells, Cultured, Skin, Melanins, Pharmacology, integumentary system, Esters, General Medicine, Molecular biology, In vitro, Staining, 030104 developmental biology, chemistry, Cinnamates, Cell culture, Melanocytes, medicine.symptom |
| الوصف: | Background/Aims: Excessive melanogenesis often causes unaesthetic hyperpigmentation. In a previous report, our group introduced a newly synthesized depigmentary agent, Melasolv™ (3,4,5-trimethoxycinnamate thymol ester). In this study, we demonstrated the significant whitening efficacy of Melasolv using various melanocytes and human skin equivalents as in vitro experimental systems. Methods: The depigmentary effect of Melasolv was tested in melan-a cells (immortalized normal murine melanocytes), α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 murine melanoma cells, primary normal human melanocytes (NHMs), and human skin equivalent (MelanoDerm). The whitening efficacy of Melasolv was further demonstrated by photography, time-lapse microscopy, Fontana-Masson (F&M) staining, and 2-photon microscopy. Results: Melasolv significantly inhibited melanogenesis in the melan-a and α-MSH-stimulated B16 cells. In human systems, Melasolv also clearly showed a whitening effect in NHMs and human skin equivalent, reflecting a decrease in melanin content. F&M staining and 2-photon microscopy revealed that Melasolv suppressed melanin transfer into multiple epidermal layers from melanocytes as well as melanin synthesis in human skin equivalent. Conclusion: Our study showed that Melasolv clearly exerts a whitening effect on various melanocytes and human skin equivalent. These results suggest the possibility that Melasolv can be used as a depigmentary agent to treat pigmentary disorders as well as an active ingredient in cosmetics to increase whitening efficacy. |
| تدمد: | 1660-5535 1660-5527 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb2c9885b53b1816bff4b64068ecbecTest https://doi.org/10.1159/000477356Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2fb2c9885b53b1816bff4b64068ecbec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16605535 16605527 |
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