Interferon-γ Inhibits in vitro Mobilization of Eosinophils by Interleukin-5
| العنوان: | Interferon-γ Inhibits in vitro Mobilization of Eosinophils by Interleukin-5 |
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| المؤلفون: | Choon-Sik Park, Yun Sung Choi, Tai Youn Rhim, Eun Nam Choi, Hun Soo Chang, Il Yup Chung, Jungsun Kim |
| المصدر: | International Archives of Allergy and Immunology. 136:295-302 |
| بيانات النشر: | S. Karger AG, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_treatment, Immunology, Inflammation, In Vitro Techniques, Allergic inflammation, Th2 Cells, Humans, Immunology and Allergy, Medicine, Eosinophilia, Interferon gamma, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Cell Shape, Interleukin 5, business.industry, General Medicine, Th1 Cells, Eosinophil, Eosinophils, Chemotaxis, Leukocyte, Cytokine, medicine.anatomical_structure, Cytokines, Tumor necrosis factor alpha, medicine.symptom, business, medicine.drug |
| الوصف: | Background: Th2 cytokines play pivotal roles in allergic inflammation, including eosinophilia, and their actions are antagonized by Th1 cytokines, conferring them therapeutic potential. Methods: In this study, we examined the ability of a number of cytokines to suppress the activation of eosinophils that function as effector cells for allergic airway diseases. Results: Interleukin (IL)-5, IL-6, and tumor necrosis factor (TNF) induced an eosinophil shape change, whereas interferon (IFN)-γ significantly inhibited the shape change. Other cytokines, including IL-1β, IL-4, IL-10 and IL-13, had little or only slightly enhancing or reducing effects on the shape change. We further analyzed the IFN-γ effect, showing that pretreatment with IFN-γ strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-γ, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. In agreement with these results, IFN-γ blocked the eosinophil migration and ERK phophorylation induced by IL-5, and the addition of CHX restored eosinophil chemotaxis. Conclusions: Collectively, IFN-γ may attenuate eosinophilic inflammation by directly negating eosinophil mobilization. |
| تدمد: | 1423-0097 1018-2438 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d3082531ca26402e04b3d1ddfaa0bcTest https://doi.org/10.1159/000083957Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....10d3082531ca26402e04b3d1ddfaa0bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
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