Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis
| العنوان: | Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis |
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| المؤلفون: | Narges Valizadeh, Hamid Reza Jahantigh, Houshang Rafatpanah, Asadollah Mohammadi, Samira Basharkhah, Seyed Abdolrahim Rezaee, Sayed-Hamidreza Mozhgani |
| المصدر: | Neurodegenerative Diseases. 18:150-155 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Retroviridae Proteins, Human T-lymphotropic virus, Asymptomatic, Interferon Lambda, Pathogenesis, Young Adult, 03 medical and health sciences, Myelopathy, Proviruses, immune system diseases, Interferon, Tropical spastic paraparesis, medicine, Humans, Receptors, Cytokine, Inverse correlation, Aged, Receptors, Interferon, Interferon type III, Human T-lymphotropic virus 1, biology, business.industry, Genes, pX, Interleukins, virus diseases, Middle Aged, medicine.disease, biology.organism_classification, Paraparesis, Tropical Spastic, Basic-Leucine Zipper Transcription Factors, 030104 developmental biology, Neurology, Immunology, Leukocytes, Mononuclear, Female, Interferons, Neurology (clinical), medicine.symptom, business, medicine.drug |
| الوصف: | HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP. Here, we investigated the host-virus interactions in the manifestation of HAM/TSP, using IL28B, IL29, IL28R, HTLV-1 Tax, HTLV-1 basic leucine zipper factor (HBZ), and proviral load (PVL). The study groups consisted of 20 patients with HAM/TSP, 20 asymptomatic HTLV-1 carriers (ACs), and 20 healthy controls (HCs). The means of PVL, Tax, and HBZ gene expressions in the HAM/TSP group (p = 0.004, 0.006, and < 0.0001, respectively) were significantly higher than in the AC group. The comparison of IL28B, IL29, and IL28R expression in the HAM/TSP, AC, and HC groups revealed no significant difference between the first 2, but lower concentrations in the HCs (IL28B: p = 0.03, 0.01; IL29: p = 0.07, 0.01; and IL28R: p < 0.0001, respectively). In the HAM/TSP group, correlations were seen between Tax and HBZ (R = 0.61, p = 0.004) and between Tax and IL29 (R = 0.45, p = 0.04). Negative correlations were observed between Tax and IL28B (R = –0.49, p = 0.02) and between HBZ and IL28R (R = –0.43, p = 0.06). In the ACs, an inverse correlation was found between Tax and IL28B (R = –0.42, p = 0.06). These findings suggest that IL29, IL28B, and IL28R interfere in the infection of HAM/TSP, mainly via Tax activation. |
| تدمد: | 1660-2862 1660-2854 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608cbf48127e64648204b95acb01f7c2Test https://doi.org/10.1159/000490058Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....608cbf48127e64648204b95acb01f7c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16602862 16602854 |
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