Levels of Endocan, Angiopoietin-2, and Hypoxia-Inducible Factor-1a in Patients with Autosomal Dominant Polycystic Kidney Disease and Different Levels of Renal Function
| العنوان: | Levels of Endocan, Angiopoietin-2, and Hypoxia-Inducible Factor-1a in Patients with Autosomal Dominant Polycystic Kidney Disease and Different Levels of Renal Function |
|---|---|
| المؤلفون: | Charalampos Loutradis, Pantelis Sarafidis, Athanasios Sioulis, Constantinos Bakogiannis, V. Raptis, Ioanna Lampropoulou, Elias V. Balaskas, Elena Intzevidou, Afroditi K. Boutou |
| المصدر: | American Journal of Nephrology. 47:231-238 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Angiogenesis, 030232 urology & nephrology, Autosomal dominant polycystic kidney disease, Renal function, urologic and male genital diseases, Angiopoietin-2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Humans, Endothelial dysfunction, Hypoxia, Neovascularization, Pathologic, business.industry, Case-control study, Middle Aged, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Polycystic Kidney, Autosomal Dominant, medicine.disease, Neoplasm Proteins, 030104 developmental biology, Endocrinology, chemistry, Nephrology, Case-Control Studies, Female, Proteoglycans, Endothelium, Vascular, medicine.symptom, business, Asymmetric dimethylarginine, Biomarkers, Vasoconstriction, Glomerular Filtration Rate |
| الوصف: | Background: Endothelial dysfunction leading to unbalanced vasoconstriction and ischemia of renal parenchyma is increasingly proposed as an alternative pathway of renal damage in autosomal dominant polycystic kidney disease (ADPKD). However, human studies investigating the evolution of such phenomena are limited. This study investigated the levels of emerging biomarkers of endothelial function, angiogenesis and hypoxia, in ADPKD patients with different renal function. Methods: The study population consisted of three groups: 26 ADPKD patients with impaired renal function (Group A; estimated glomerular filtration rate [eGFR] 45–70 mL/min/1.73 m2), 26 ADPKD patients with preserved renal function (Group B; eGFR >70 mL/min/1.73 m2), and 26 age- and sex-matched controls with no history of renal disease. Circulating levels of endocan (endothelial cell-specific molecule-1) angiopoietin-2, and hypoxia-inducible factor-1a (HIF-1a) were determined by enzyme-linked immunosorbent assay techniques. Results: Patients in Group A had significantly higher levels of endocan (7.17 ± 0.43 ng/mL), angiopoietin-2 (5,595.43 ± 3,390), and HIF-1a (163.68 ± 37.84 pg/mL) compared to patients in Group B (6.86 ± 0.59 ng/mL, p = 0.017, 3,854.41 ± 3,014.30, p = 0.018, 136.84 ± 42.10 pg/mL, p = 0.019 respectively) or controls (4.83 ± 0.69 ng/mL, 1,069 ± 427.88 pg/mL, 70.20 ± 17.49 pg/mL, p < 0.001 for all comparisons). Of note, patients in Group B had also higher levels of all markers compared to controls (p < 0.001) despite having similar renal function. In correlation analyses within ADPKD patients, we noted strong correlations of all studied markers with asymmetric dimethylarginine (ADMA; endocan r = 0.908, p < 0.001, angiopoietin-2 r = 0.983, p < 0.001 and HIF-1a r = 0.998, p < 0.001), and only weak or modest correlations with eGFR. Conclusions: This study suggests that endothelial dysfunction causing microcirculatory changes, linked to angiogenesis and hypoxia, may come early in the course of ADPKD and could be a key regulator of renal injury progression. |
| تدمد: | 1421-9670 0250-8095 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6489b42cd6163e3fab0fd4f605a59dadTest https://doi.org/10.1159/000488115Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6489b42cd6163e3fab0fd4f605a59dad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219670 02508095 |
|---|