دورية أكاديمية
Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment
| العنوان: | Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment |
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| المؤلفون: | Kalbe, E., Salmon, Eric, Perani, D., Holthoff, V., Sorbi, S., Elsner, A., Weisenbach, S., Brand, M., Lenz, O., Kessler, J., Luedecke, S., Ortelli, P., Herholz, K. |
| المصدر: | Dementia and Geriatric Cognitive Disorders, 19 (5-6), 349-356 (2005) |
| بيانات النشر: | S. Karger |
| سنة النشر: | 2005 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | anosognosia, self awareness, insight, dementia, cognitive dysfunction, Alzheimer's disease, mild cognitive impairment, Social & behavioral sciences, psychology, Sociology & social sciences, Human health sciences, Neurology, Sciences sociales & comportementales, psychologie, Sociologie & sciences sociales, Sciences de la santé humaine, Neurologie |
| الوصف: | peer reviewed ; Objective: To study awareness of cognitive dysfunction in patients with very mild Alzheimer's disease (AD) and subjects with mild cognitive impairment (MCI). Methods: A complaint interview covering 13 cognitive domains was administered to 82 AD and 79 MCI patients and their caregivers. The patient groups were comparable according to age and education, and Mini Mental State Examination (MMSE) scores were ≥ 24 in all cases. The discrepancy between the patients' and caregivers' estimations of impairments was taken as a measure of anosognosia. Results: Self-reports of cognitive difficulties were comparable for AD and MCI patients. However, while in comparison to caregivers MCI patients reported significantly more cognitive impairment (p < 0.05), AD patients complained significantly less cognitive dysfunctions (p < 0.001). Conclusions: While most MCI patients tend to overestimate cognitive deficits when compared to their caregiver's assessment, AD patients in early stages of disease underestimate cognitive dysfunctions. Anosognosia can thus be regarded as a characteristic symptom at a stage of very mild AD (MMSE ≥ 24) but not MCI. Accordingly, medical history even in mildly affected patients should always include information from both patient and caregiver. Copyright (C) 2005 S. Karger AG, Basel. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1420-8008 1421-9824 |
| العلاقة: | urn:issn:1420-8008; urn:issn:1421-9824; https://orbi.uliege.be/handle/2268/61949Test; info:hdl:2268/61949; scopus-id:2-s2.0-20844432210; info:pmid:15802909 |
| DOI: | 10.1159/000084704 |
| الإتاحة: | https://doi.org/10.1159/000084704Test https://orbi.uliege.be/handle/2268/61949Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.ADC35B1C |
| قاعدة البيانات: | BASE |
| تدمد: | 14208008 14219824 |
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| DOI: | 10.1159/000084704 |