Diet containing stearic acid increased food intake in mice by reducing serum leptin compared with oleic acid
| العنوان: | Diet containing stearic acid increased food intake in mice by reducing serum leptin compared with oleic acid |
|---|---|
| المؤلفون: | Shuqing Zhu, Xiaohua Feng, Xiajie Feng, Kailai Xie, Yongxiang Li, Lvshuang Chen, Yingfen Mo, Jingwen Liang, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Qingyan Jiang, Lina Wang |
| المصدر: | Food & Function. 14:990-1002 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Medicine, Food Science |
| الوصف: | In today's society, obesity is becoming increasingly serious, and controlling food intake and maintaining weight balance have become increasingly important. Here, we found that a stearic acid diet can increase food intake without causing obesity in mice compared with an oleic acid diet. Stearic acid increases food intake in mice by reducing serum leptin and increasing NPY neuronal excitability through the JAK2/STAT3 pathway. The impaired anorexic effect of leptin is probably due to repressive cholesterol-oxysterol-LXR-α/SREBP-1c-mediated leptin expression in mouse iWAT. At the same time, we found that stearic acid was not only poorly absorbed by itself in the small intestine but also reduced the entire absorption system of the small intestine. In conclusion, we have proven that a stearic acid diet can increase food intake in mice and avoid obesity, but whether a stearic acid diet could cause adverse reactions in the body remains to be studied. |
| تدمد: | 2042-650X 2042-6496 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6463f1ff7f3b31f7d916eb0ddeac8525Test https://doi.org/10.1039/d2fo03051aTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6463f1ff7f3b31f7d916eb0ddeac8525 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2042650X 20426496 |
|---|