A metal–organic framework based inner ear delivery system for the treatment of noise-induced hearing loss
| العنوان: | A metal–organic framework based inner ear delivery system for the treatment of noise-induced hearing loss |
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| المؤلفون: | Xiuping Yang, Xiaoxiang Xu, Zuhong He, Yu Sun, Kun Lin, Ya Zhang, Kai Xu, Haoquan Zheng, Minlan Yang, Xiong Chen, Yanzhi Wang |
| المصدر: | Nanoscale. 12:16359-16365 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Biocompatibility, Hearing loss, medicine.medical_treatment, Intraperitoneal injection, 02 engineering and technology, Pharmacology, 010402 general chemistry, 01 natural sciences, Nephrotoxicity, Mice, otorhinolaryngologic diseases, medicine, Animals, General Materials Science, Inner ear, Metal-Organic Frameworks, Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, Steroid hormone, medicine.anatomical_structure, Hearing Loss, Noise-Induced, Ear, Inner, Zeolites, Nanoparticles, medicine.symptom, 0210 nano-technology, Noise-induced hearing loss, Hormone |
| الوصف: | Noise-induced hearing loss (NIHL) is associated with both acute and chronic noise exposure. The application of steroid hormones is the first-line treatment for NIHL. However, a high dose of steroid hormone in the body is necessary to maintain its efficacy and causes side effects, such as headache and osteoporosis. In this work, we prepared a zeolitic imidazolate framework (ZIF)-based system for steroid hormone delivery in the inner ear. Methylprednisolone (MP), a typical steroid hormone, was encapsulated into ZIF-90 nanoparticles (NPs) using one-pot synthesis method. The obtained MP@ZIF-90 NPs are negatively charged and 120 nm in size and showed good biocompatibility and stability at a pH value of 7.4. After intraperitoneal injection, ZIF-90 could efficiently protect drugs during peripheral blood circulation, enter the inner ear via the blood labyrinthine barrier (BLB) and slowly release the drugs. Auditory brainstem response (ABR) tests indicated that MP@ZIF-90 exhibits better protection of mice from noise than those using the free MP and ZIF-8 with encapsulated MP (MP@ZIF-8). More importantly, MP@ZIF-90 showed no defects to the inner ear after being treated for noise and low nephrotoxicity during therapy, which demonstrates the biocompatibility of this material. We believe the ZIF-90 based delivery system is an efficient strategy for inner ear therapy of NIHL. |
| تدمد: | 2040-3372 2040-3364 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7d5a476f8765b1fbca55a48a3224efTest https://doi.org/10.1039/d0nr04860gTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6a7d5a476f8765b1fbca55a48a3224ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20403372 20403364 |
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