Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation
| العنوان: | Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation |
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| المؤلفون: | R. Paul Ross, Wei Chen, Zhujun He, Catherine Stanton, Jianxin Zhao, Bo Yang, Yonghua Zhou, Hao Zhang, Yue Yue |
| المصدر: | Food & Function. 11:10362-10374 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Diarrhea, 0301 basic medicine, 030106 microbiology, Enterotoxin, Gut flora, medicine.disease_cause, digestive system, Microbiology, law.invention, Enterotoxins, Feces, Interferon-gamma, Mice, 03 medical and health sciences, Probiotic, fluids and secretions, law, Enterotoxigenic Escherichia coli, Escherichia coli, medicine, Animals, Escherichia coli Infections, Bifidobacterium, Inflammation, Mice, Inbred BALB C, biology, Interleukin-6, Tumor Necrosis Factor-alpha, Probiotics, Body Weight, food and beverages, General Medicine, biology.organism_classification, Gastrointestinal Microbiome, Disease Models, Animal, Jejunum, 030104 developmental biology, Cytokines, Female, medicine.symptom, Lactobacillus plantarum, Food Science |
| الوصف: | Lactobacillus plantarum can relieve diarrhea caused by enterotoxigenic Escherichia coli (ETEC), but the remission mechanism has not been fully explained. This study compares the ability of four Lactobacillus plantarum strains from different niches to alleviate diarrhea caused by ETEC infection and explores their potential remission manner. The results showed that Lactobacillus plantarum CCFM1143 had the most obvious protective effect on diarrhea caused by ETEC. FGDLZ1M5, FCQNA30M6 and CCFM1143 reduced tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and interleukin (IL)-6 as well as jejunal injury. Moreover, FCQNA30M6 and CCFM1143 increased the aquaporin AQP3, and CCFM1143 increased interleukin (IL)-10 and decreased heat-stable enterotoxin (ST), while FGDLZ1M5 reduced the toll-like receptor (TLR4). The gut microbiota analysis demonstrated that ETEC increased Proteus and Pseudomonas and reduced Bifidobacterium, Odoribacter, Allobaculum and Blautia. A supplement of Lactobacillus plantarum could reconstruct the unbalanced gut microbiota. Furthermore, CCFM1143 significantly increased butyric acid, acetic acid, propionic acid and isobutyric acid, while FGDLZ1M5 only increased butyric acid. In summary, Lactobacillus plantarum alleviated ETEC-induced diarrhea by regulating the inflammatory cytokines, rebalancing the gut microbiota and modulating short-chain fatty acids (SCFAs) generation, which could provide the foundation and support for subsequent clinical trials and probiotic products. |
| تدمد: | 2042-650X 2042-6496 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d21e22146fd915054271a7031a7f7a9Test https://doi.org/10.1039/d0fo02670kTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7d21e22146fd915054271a7031a7f7a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2042650X 20426496 |
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