In situ construction of nanonetworks from transformable nanoparticles for anti-angiogenic therapy
| العنوان: | In situ construction of nanonetworks from transformable nanoparticles for anti-angiogenic therapy |
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| المؤلفون: | Hao Wang, Pei-Pei Yang, Lei Wang, Jingping Zhang, Bing-Nan Li, Ping-Ping He |
| المصدر: | Journal of Materials Chemistry B. 6:5282-5289 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, In situ, Chemistry, Angiogenesis, Cell, Biomedical Engineering, Cancer, 02 engineering and technology, General Chemistry, General Medicine, 021001 nanoscience & nanotechnology, medicine.disease, Metastasis, Vascular endothelial growth factor, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Extracellular, medicine, General Materials Science, 0210 nano-technology, Receptor |
| الوصف: | Tumor metastasis as the most common reason of death from cancer has always been a great challenge in both clinical and scientific research, where angiogenesis plays a necessary role. Herein, we report an extracellularly transformable nanomaterial for in situ construction of defensive networks on interaction with vascular endothelial growth factor (VEGF) for anti-angiogenic therapy of tumor. The fibrous networks exhibit transformation-enhanced accumulation and retention (TEAR) effects (over 72 h), and bind and intercept cell-secreted VEGF over particulate and molecular anti-angiogenic agents with high efficiency, leading to anti-angiogenesis. This study demonstrates that angiogenesis is positively related to tumor growth as well as tumor metastasis; the anti-angiogenic therapy inhibits tumor metastasis with an inhibition rate of 65.9%. In addition, this extracellular strategy of transformation may be utilized to bind huge amounts of cell-secreted biomolecules/factors or receptors on cell surfaces and inhibit their functionalities for cancer therapy. |
| تدمد: | 2050-7518 2050-750X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3a9b357a1217a2bf53267f8ab42532Test https://doi.org/10.1039/c8tb00974kTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2f3a9b357a1217a2bf53267f8ab42532 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20507518 2050750X |
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