The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicity
| العنوان: | The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicity |
|---|---|
| المؤلفون: | Pooja Mehta, Shalmoli Bhattacharyya |
| المصدر: | Food Funct.. 3:164-169 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Antioxidant, medicine.medical_treatment, Ascorbic Acid, Pharmacology, Lipid peroxidation, Mice, chemistry.chemical_compound, Spirulina, medicine, Animals, Aspartate Aminotransferases, Spirulina (genus), Liver injury, chemistry.chemical_classification, Cisplatin, Mice, Inbred BALB C, L-Lactate Dehydrogenase, biology, Vitamin C, Vitamins, General Medicine, Alkaline Phosphatase, biology.organism_classification, medicine.disease, Diet, Enzyme, Liver, chemistry, Biochemistry, Dietary Supplements, Toxicity, Female, Lipid Peroxidation, Food Science, medicine.drug |
| الوصف: | Spirulina platensis is a microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-carcinogenic properties. We investigated the mechanism of cisplatin induced hepatotoxicity and whether this natural antioxidant provided protection against cisplatin hepatotoxicity. The study was carried out in a mice model where the animals were segregated into different groups according to their treatments, e.g. control group with no treatment, cisplatin treated, cisplatin + Spirulina treated, cisplatin + vitamin C treated and cisplatin + Spirulina + vitamin C treated. The liver marker enzymes were found to be elevated following cisplatin treatment, signifying hepatotoxicity. The supplementation of Spirulina and vitamin C could effectively bring down the levels of these enzymes. Light microscopy also showed that cisplatin treatment induced liver injury and that histopathological abnormalities were prevented by Spirulina and vitamin C supplementation. This protective effect was further substantiated by the estimation of antioxidant levels and extent of lipid peroxidation in the Spirulina, vitamin C and Spirulina + vitamin C supplemented groups as compared to cisplatin alone. |
| تدمد: | 2042-650X 2042-6496 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f4858d762470b66248ebded32c7b9aTest https://doi.org/10.1039/c1fo10172bTest |
| رقم الانضمام: | edsair.doi.dedup.....c4f4858d762470b66248ebded32c7b9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2042650X 20426496 |
|---|