Coiled coil peptide-functionalized surfaces for reversible molecular binding
| العنوان: | Coiled coil peptide-functionalized surfaces for reversible molecular binding |
|---|---|
| المؤلفون: | Caterina Minelli, Murugesan Muthu, Heiko Andresen, Jian X. Liew |
| المصدر: | Soft Matter. 9:5119 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Coiled coil, chemistry.chemical_classification, Polarity (international relations), Chemistry, Molecular binding, Peptide, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Peptide Conformation, Solvent, chemistry.chemical_compound, Crystallography, Colloidal gold, Biophysics, 0210 nano-technology, Acetonitrile |
| الوصف: | We studied the conformational and self-assembly properties of de novo peptides derived from the structure of the yeast transcriptional activator GCN4 in solution and on surfaces. We showed how the pH and the polarity of the solvent directed peptide conformation and assembly. The peptides self-assembled into a coiled coil structure below pH 5 whereas they disassembled above pH 7. The presence of acetonitrile in the peptide solution influenced the peptide's ability to assemble into a coiled coil structure while retaining its alpha-helix conformation. We used these properties to control the peptide packing density on gold surfaces and demonstrated that such peptide-engineered surfaces could be used for reversible molecular binding by utilising functionalised gold nanoparticles. |
| تدمد: | 1744-6848 1744-683X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::5be689b5305791bc8042a575883ffc5aTest https://doi.org/10.1039/c3sm50379hTest |
| رقم الانضمام: | edsair.doi...........5be689b5305791bc8042a575883ffc5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17446848 1744683X |
|---|