التفاصيل البيبلوغرافية
| العنوان: |
Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array. |
| المؤلفون: |
Waheb Bishara, Uzair Sikora, Onur Mudanyali, Ting-Wei Su, Oguzhan Yaglidere, Shirley Luckhart, Aydogan Ozcan |
| المصدر: |
Lab on a Chip; Apr2011, Vol. 11 Issue 7, p1276-1279, 4p |
| مصطلحات موضوعية: |
HIGH resolution imaging, HOLOGRAPHY, MICROSCOPY, FIBER optics, COHERENCE (Physics), LIGHT emitting diodes, PERFORMANCE evaluation, PLASMODIUM |
| مستخلص: |
We report a portable lensless on-chip microscope that can achieve <1 µm resolution over a wide field-of-view of ∼24 mm2without the use of any mechanical scanning. This compact on-chip microscope weighs ∼95 g and is based on partially coherent digital in-line holography. Multiple fiber-optic waveguides are butt-coupled to light emitting diodes, which are controlled by a low-cost micro-controller to sequentially illuminate the sample. The resulting lensfree holograms are then captured by a digital sensor-array and are rapidly processed using a pixel super-resolution algorithm to generate much higher resolution holographic images (both phase and amplitude) of the objects. This wide-field and high-resolution on-chip microscope, being compact and light-weight, would be important for global health problems such as diagnosis of infectious diseases in remote locations. Toward this end, we validate the performance of this field-portable microscope by imaging human malaria parasites (Plasmodium falciparum) in thin blood smears. Our results constitute the first-time that a lensfree on-chip microscope has successfully imaged malaria parasites. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
