التفاصيل البيبلوغرافية
| العنوان: |
Development of inositol-based antagonists for the d-myo-inositol 1,4,5-trisphosphate receptorThis article is part of the ‘Emerging Investigators’ themed issue for ChemComm.Electronic supplementary information (ESI) available: Additional biological data, compound characterisation data and NMR spectra for compounds 2–5. See DOI: 10.1039/c0cc03003a |
| المؤلفون: |
KeddieThese authors contributed equally to this work., Neil S., Ye, Yulin, Aslam, Tashfeen, Luyten, Tomas, Bello, Davide, Garnham, Clive, Bultynck, Geert, Galione, Antony, Conway, Stuart J. |
| المصدر: |
Chemical Communications; Dec2010, Vol. 47 Issue 1, p242-244, 3p |
| مصطلحات موضوعية: |
INOSITOL, PHOSPHATES, ORGANIC synthesis, DRUG development, ESTERS, SULFATES, CHEMICAL reactions |
| مستخلص: |
The syntheses of four d-myo-inositol 1,4,5-trisphosphate (InsP3) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP3receptor (InsP3R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP3R antagonists. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
