The Lauren Classification Highlights the Role of Epithelialto- Mesenchymal Transition in Gastric Carcinogenesis: an Immunohistochemistry Study of the STAT3 and Adhesion Molecules Expression
| العنوان: | The Lauren Classification Highlights the Role of Epithelialto- Mesenchymal Transition in Gastric Carcinogenesis: an Immunohistochemistry Study of the STAT3 and Adhesion Molecules Expression |
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| المؤلفون: | Sergiu Susman, Francesco Borini, Jean-Cristophe Sabourin, Ciprian Tomuleasa, Frederique Bibeau, Raphaelle Barnoud, Marc Pocard |
| المساهمون: | Lyon University Hospital Croix-Rouge, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut Gustave Roussy (IGR), Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, CHU Rouen, Normandie Université (NU), La Sapienza University, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7) |
| المصدر: | Journal of Gastrointestinal and Liver Diseases Journal of Gastrointestinal and Liver Diseases, Romanian Societies of Gastroenterology, 2015, 24 (1), pp.77-83. ⟨10.15403/jgld.2014.1121.sus⟩ |
| بيانات النشر: | Romanian Society of Gastroenterology and Hepatology, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, STAT3 Transcription Factor, Pathology, medicine.medical_specialty, Epithelial-Mesenchymal Transition, [SDV.CAN]Life Sciences [q-bio]/Cancer, Adenocarcinoma, medicine.disease_cause, CDH1, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, Stomach Neoplasms, Biomarkers, Tumor, medicine, Humans, Epithelial–mesenchymal transition, Phosphorylation, beta Catenin, Aged, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, Tissue microarray, biology, Cell adhesion molecule, Gastroenterology, Cancer, Middle Aged, Cadherins, Prognosis, medicine.disease, Immunohistochemistry, Phenotype, 3. Good health, Europe, Tissue Array Analysis, 030220 oncology & carcinogenesis, biology.protein, Female, Carcinogenesis, Cell Adhesion Molecules, alpha Catenin |
| الوصف: | Background & Aims: Despite some recent advances, gastric cancer remains an important cause of death at world level. This indicates an absence of therapeutic options, stemming from the limited understanding of the molecular mechanisms involved in carcinogenesis. Nearly fifty years ago Lauren classified gastric cancers, according to the morphological aspect, as intestinal or diffuse. The phenotype of the cells indicates the presence of different molecular mechanisms, which can be approached in the light of recent data and identified with the help of current techniques. The best described are the germline/somatic mutations or the hypermethylations of the E-cadherin 1 CDH1 gene promotor.Methods. We analyzed 195 gastric tumors,120 intestinal and 75 diffuse type, using immunohistochemistry (tissue microarray TMA method) for pStat3Tyr705, E-cadherin, α-catenin and β-catenin; 985 spots of gastric tumors, distributed on 4 TMA blocks were analyzed. For pStat3Tyr705 we took the nuclear staining into account and for the adhesion molecules, membrane staining.Results. In our study, in the diffuse type gastric cancer, pStat3Tyr705 nuclear expression was statistically significantly increased (p=0.003). Also we observed a decreased expression of the adhesion molecules in the same type of gastric cancer (E-cadherin p |
| تدمد: | 1842-1121 1841-8724 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30511c3cf47f190128f193ccff12e1a9Test https://doi.org/10.15403/jgld.2014.1121.susTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....30511c3cf47f190128f193ccff12e1a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18421121 18418724 |
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