Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease
| العنوان: | Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease |
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| المؤلفون: | Jason D. Fontenot, Blythe D. Sather, Piper R. Treuting, Nikole Perdue, Alexander Y. Rudensky, Mike Miazgowicz, Daniel J. Campbell |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Receptors, CCR4, Receptor expression, Immunology, Cell, chemical and pharmacologic phenomena, Biology, T-Lymphocytes, Regulatory, Article, Mice, 03 medical and health sciences, Interleukin 21, Chemokine receptor, 0302 clinical medicine, Antigens, CD, medicine, Animals, Immunology and Allergy, Cytotoxic T cell, IL-2 receptor, Skin, 030304 developmental biology, Inflammation, Mice, Inbred BALB C, 0303 health sciences, FOXP3, Peripheral tolerance, Forkhead Transcription Factors, hemic and immune systems, Articles, Flow Cytometry, Adoptive Transfer, 3. Good health, Cell biology, Mice, Inbred C57BL, Self Tolerance, medicine.anatomical_structure, Integrin alpha Chains, 030215 immunology |
| الوصف: | CD4+Foxp3+ regulatory T cells (T reg) are essential for maintaining self-tolerance, but their functional mechanisms and sites of action in vivo are poorly defined. We examined the homing receptor expression and tissue distribution of T reg cells in the steady state and determined whether altering their distribution by removal of a single chemokine receptor impairs their ability to maintain tissue-specific peripheral tolerance. We found that T reg cells are distributed throughout all nonlymphoid tissues tested, and are particularly prevalent in the skin, where they express a unique CCR4+CD103hi phenotype. T reg cell expression of CCR4 and CD103 is induced by antigen-driven activation within subcutaneous lymph nodes, and accumulation of T reg cells in the skin and lung airways is impaired in the absence of CCR4 expression. Mice with a complete loss of CCR4 in the T reg cell compartment develop lymphocytic infiltration and severe inflammatory disease in the skin and lungs, accompanied by peripheral lymphadenopathy and increased differentiation of skin-tropic CD4+Foxp3+ T cells. Thus, selectively altering T reg cell distribution in vivo leads to the development of tissue-specific inflammatory disease. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d95ea0efddbbdad5f01d9d7c9ce7b11Test https://doi.org/10.1084/jem.20070081Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d95ea0efddbbdad5f01d9d7c9ce7b11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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