Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites
| العنوان: | Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites |
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| المؤلفون: | Vivian L. Braciale, Marianne T. Sweetser, T J Braciale |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Molecular Sequence Data, Immunology, Orthomyxoviridae, Hemagglutinins, Viral, Hemagglutinin (influenza), Mice, Inbred Strains, medicine.disease_cause, Major histocompatibility complex, Epitope, Major Histocompatibility Complex, Epitopes, Mice, Structure-Activity Relationship, Antigen, Influenza A virus, medicine, Animals, Immunology and Allergy, Cytotoxic T cell, Amino Acid Sequence, HN Protein, biology, H-2 Antigens, Articles, biology.organism_classification, Virology, biology.protein, Oligopeptides, CD8, T-Lymphocytes, Cytotoxic |
| الوصف: | The influenza hemagglutinin is a critical regulator of disease expression during influenza virus infection and serves as a major target for the host immune response to this pathogen. In this report, we have analyzed an immunodominant site on the hemagglutinin (residues 202-221) recognized by murine class I MHC-restricted T lymphocytes. This analysis has revealed evidence for the duplication of a T cell recognition site within the region 202-221. We have also identified critical amino acids necessary for class I-restricted T cell recognition within these two epitopes. In addition, we provide evidence that a site on the influenza hemagglutinin recognized by neutralizing antibody directly overlaps with an epitope recognized by class I MHC-restricted CTL. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780038fc9d5d51cb1906634214540c08Test https://doi.org/10.1084/jem.170.4.1357Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....780038fc9d5d51cb1906634214540c08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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