Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria
| العنوان: | Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria |
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| المؤلفون: | Geoffrey T. Hart, Sumati Rajagopalan, Gunjan Arora, Peter D. Crompton, Yenan T. Bryceson, Tuan M. Tran, A. D. Jules Sangala, Boubacar Traore, Eric O. Long, Heinrich Schlums, Susan K. Pierce, Kerry J. Welsh, Jakob Theorell |
| المصدر: | Journal of Experimental Medicine. 216:1280-1290 |
| بيانات النشر: | Rockefeller University Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, biology, Immunology, Fc receptor, Plasmodium falciparum, Parasitemia, biology.organism_classification, medicine.disease, Acquired immune system, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Antigen, Immunity, 030220 oncology & carcinogenesis, parasitic diseases, biology.protein, medicine, Immunology and Allergy, Antibody, Malaria |
| الوصف: | How antibodies naturally acquired during Plasmodium falciparum infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-parameter flow cytometry revealed a high proportion of adaptive NK cells, which are defined by the loss of transcription factor PLZF and Fc receptor γ-chain. Adaptive NK cells dominated antibody-dependent cellular cytotoxicity responses, and their frequency within total NK cells correlated with lower parasitemia and resistance to malaria. P. falciparum–infected RBCs induced NK cell degranulation after addition of plasma from malaria-resistant individuals. Malaria-susceptible subjects with the largest increase in PLZF-negative NK cells during the transmission season had improved odds of resistance during the subsequent season. Thus, antibody-dependent lysis of P. falciparum–infected RBCs by NK cells may be a mechanism of acquired immunity to malaria. Consideration of antibody-dependent NK cell responses to P. falciparum antigens is therefore warranted in the design of malaria vaccines. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::5d0c701102fe52bf2b1d2e7e4db08de4Test https://doi.org/10.1084/jem.20181681Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........5d0c701102fe52bf2b1d2e7e4db08de4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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