Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice
| العنوان: | Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice |
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| المؤلفون: | Florian Otto, Michael J. Owen, Meg Mathies, Cornelia Berlin-Rufenach, Juergen Westermann, Alf Hamann, Nancy Hogg |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | bone marrow, integrin, Lymphoid Tissue, Integrin alpha4, Lymphocyte, Immunology, Integrin, High endothelial venules, lymphocyte, Ligands, Mice, Antigens, CD, Cell Movement, Cell Adhesion, Addressin, medicine, Animals, Immunology and Allergy, Lymphocytes, Lymphocyte function-associated antigen 1, Cell adhesion, Lymphocyte homing receptor, Mice, Knockout, biology, Cell adhesion molecule, hemic and immune systems, Articles, Lymphocyte Function-Associated Antigen-1, Cell biology, Mice, Inbred C57BL, adhesion, medicine.anatomical_structure, Gene Targeting, biology.protein, homing |
| الوصف: | Using lymphocyte function-associated antigen (LFA)-1(-/-) mice, we have examined the role of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in migration to peripheral lymph nodes (pLNs), and influences migration into other LNs. Second, the alpha4 integrins, alpha4beta7 and alpha4beta1, have a hitherto unrecognized ability to compensate for the lack of LFA-1 in migration to pLNs. These findings are confirmed using normal mice and blocking LFA-1 and alpha4 monoclonal antibodies. Unexpectedly, vascular cell adhesion molecule (VCAM)-1, which is essential in inflammatory responses, serves as the ligand for the alpha4 integrins on pLN high endothelial venules. VCAM-1 also participates in trafficking into mesenteric LNs and Peyer's patch nodes where mucosal addressin cell adhesion molecule 1 (MAdCAM-1), the alpha4beta7-specific ligand, dominates. Both alpha4beta1, interacting with ligand VCAM-1, and also LFA-1 participate in substantial lymphocyte recirculation through bone marrow. These observations suggest that organ-specific adhesion receptor usage in mature lymphocyte recirculation is not as rigidly adhered to as previously considered, and that the same basic sets of adhesion receptors are used in both lymphocyte homing and inflammatory responses. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2a69f797c2b0433ba27bc2242f99c3Test https://doi.org/10.1084/jem.189.9.1467Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5d2a69f797c2b0433ba27bc2242f99c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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