E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells
| العنوان: | E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
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| المؤلفون: | Steffen Rickelt, Caecilia Kuhn, Marcus Iken, Christine Grund, Michael Ott, Peter Schirmacher, Ralf Zimbelmann, Werner W. Franke, Beate K. Straub |
| المصدر: | The Journal of Cell Biology |
| بيانات النشر: | Rockefeller University Press, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | animal structures, Stromal cell, Swine, Biology, medicine.disease_cause, Cell junction, Article, Adherens junction, Mice, Cell Adhesion, Tumor Cells, Cultured, medicine, Animals, Humans, Cell adhesion, Research Articles, Cadherin, Endoderm, Adherens Junctions, Cell Biology, Cadherins, Rats, Cell biology, medicine.anatomical_structure, embryonic structures, Cattle, Carcinogenesis, Function (biology) |
| الوصف: | Contradicting the “cadherin switch” model, mixed E-cadherin–N-cadherin heterodimeric adherens junctions are prevalent in a variety of endodermal cells and endoderm-derived tumors. Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this “cadherin switch” hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E–N heterodimers. We also show that cells possessing E–N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin–based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered. |
| تدمد: | 1540-8140 0021-9525 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66a4e74092ea471524f3aae1b7b6d14Test https://doi.org/10.1083/jcb.201106023Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f66a4e74092ea471524f3aae1b7b6d14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408140 00219525 |
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