Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4
| العنوان: | Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4 |
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| المؤلفون: | T. Kent Teague, Anthony T. Vella, John W. Kappler, Philippa Marrack, James N. Ihle |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | T-Lymphocytes, T cell, Immunology, Biology, Article, Mice, Interleukin 21, medicine, Animals, Immunology and Allergy, Cytotoxic T cell, IL-2 receptor, Cells, Cultured, Interleukin 3, Cell Death, Interleukin-7, CD28, Natural killer T cell, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Trans-Activators, Interleukin 12, Interleukin-4, STAT6 Transcription Factor |
| الوصف: | Although much is known about the activation, proliferation, and function of CD4+ T cells, little is known about how they survive as resting T cells in animals. Resting T cells have a half-life in animals of more than a week; however, when they are removed from animals and placed in tissue culture their half-life falls to ∼24 h. In this paper, we show that the survival of resting T cells in vitro is promoted by two cytokines, interleukins 4 and 7 (IL-4, IL-7). They may do this in part by maintaining levels of survival-promoting proteins such as Bcl-2 in the cells, because the levels of Bcl-2 and Bcl-Xl in resting T cells fall rapidly after the cells are isolated from animals, and are maintained by culture in IL-4. Because the IL-4 receptor is known to signal through the JAK1 and JAK3/Stat6 pathway, we tested whether Stat6 was required for IL-4– dependent T cell survival. Surprisingly, we found that IL-4 rescued T cells from apoptosis in what appeared to be a Stat6-independent manner. These results demonstrate that the survival of resting T cells is an active process that can be affected by signals delivered by cytokines and also suggest that the IL-4 receptor on resting T cells may use a novel signaling pathway to facilitate T cell viability. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a2e135c577b32cd02525571f66570fTest https://doi.org/10.1084/jem.186.2.325Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....45a2e135c577b32cd02525571f66570f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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