PD-1 regulates KLRG1+ group 2 innate lymphoid cells
| العنوان: | PD-1 regulates KLRG1+ group 2 innate lymphoid cells |
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| المؤلفون: | Emma L. Woodward, William E. Paul, Jonathan Scott, Ming-an Sun, Nathaniel Zhu, Evelyn L. Martin, Yuefeng Huang, Samuel Taylor, Nick J. Reynolds, Daniel H. Fowler, Grace Mallett, M Elias, Tania C. Felizardo, Chaido Stathopoulou, Shoba Amarnath |
| المصدر: | Journal of Experimental Medicine. 214:1663-1678 |
| بيانات النشر: | Rockefeller University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adoptive cell transfer, biology, Immunology, Innate lymphoid cell, biology.organism_classification, body regions, 03 medical and health sciences, 030104 developmental biology, Immune system, Immunity, biology.protein, Immunology and Allergy, Nippostrongylus brasiliensis, Signal transduction, Antibody, skin and connective tissue diseases, Tissue homeostasis |
| الوصف: | Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response to cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an important negative regulator of KLRG1+ ILC-2 function in both mice and humans. Increase in KLRG1+ ILC-2 cell numbers was attributed to an intrinsic defect in PD-1 signaling, which resulted in enhanced STAT5 activation. During Nippostrongylus brasiliensis infection, a significant expansion of KLRG1+ ILC-2 subsets occurred in Pdcd1−/− mice and, upon adoptive transfer, Pdcd1−/− KLRG1+ ILC-2s significantly reduced worm burden. Furthermore, blocking PD-1 with an antibody increased KLRG1+ ILC-2 cell number and reduced disease burden. Therefore, PD-1 is required for maintaining the number, and hence function, of KLRG1+ ILC-2s. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::d5fb8251deef793c0ddb9439237721b7Test https://doi.org/10.1084/jem.20161653Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........d5fb8251deef793c0ddb9439237721b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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