Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus
| العنوان: | Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus |
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| المؤلفون: | Giuliana Trucco, William A. Rudert, A Galluzzo, Roberto Testi, Carla Giordano, Giorgio Stassi, Ruggero De Maria, Massimo Trucco |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Fas Ligand Protein, endocrine system diseases, Immunology, Apoptosis, Biology, Ligands, Nitric Oxide, Article, Fas ligand, Nitric oxide, Islets of Langerhans, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Cell Movement, T-Lymphocyte Subsets, Internal medicine, medicine, Humans, Immunology and Allergy, fas Receptor, Child, Receptor, Tissue homeostasis, 030304 developmental biology, 0303 health sciences, Membrane Glycoproteins, Articles, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Endocrinology, chemistry, Female, Sodium nitroprusside, Pancreas, Interleukin-1, 030215 immunology, medicine.drug |
| الوصف: | Fas is an apoptosis-inducing surface receptor involved in controlling tissue homeostasis and function at multiple sites. Here we show that beta cells from the pancreata of newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients express Fas and show extensive apoptosis among those cells located in proximity to Fas ligand-expressing T lymphocytes infiltrating the IDDM islets. Normal human pancreatic beta cells that do not constitutively express Fas, become strongly Fas positive after interleuken (IL)-1beta exposure, and are then susceptible to Fas-mediated apoptosis. NG-monomethyl-L-arginine, an inhibitor of nitric oxide (NO) synthase, prevents IL-1beta-induced Fas expression, whereas the NO donors sodium nitroprusside and nitric oxide releasing compound (NOC)-18, induce functional Fas expression in normal pancreatic beta cells. These findings suggest that NO-mediated upregulation of Fas contributes to pancreatic beta cell damage in IDDM. |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b37d67b38ea79f8d91a8926dab69073Test https://doi.org/10.1084/jem.186.8.1193Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b37d67b38ea79f8d91a8926dab69073 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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