مورد إلكتروني
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
| العنوان: | DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice |
|---|---|
| المصدر: | Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press 2011 |
| تفاصيل مُضافة: | Randall, Katrina Chan, Stephanie Ma, Cindy Fung, Ivan Mei, Angela (Yan) Yabas, Mehmet Tan, Andy Arkwright, Peter D Al Suwairi, Wafaa Reyes, Saul Oswaldo Lugo Yamazaki-Nakashimada, Marco A. Garcia-Cruz, Maria de la Luz Smart, Joanne M. Picard, Capucine Okada, Satoshi Jouanguy, Emmanuelle Casanova, Jean-Laurent Lambe, Teresa Cornall, Richard J Russell, Sarah Oliaro, Jane Tangye, Stuart Bertram, Edward Goodnow, Christopher |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45RA+CCR7? phenotype. Analyses in mice revealed the CD8 T cell abnormalities to be cell autonomous and primarily postthymic. DOCK8 mutant naive CD8 T cells had a shorter lifespan and, upon encounter with antigen on dendritic cells, exhibited poor LFA-1 synaptic polarization and a delay in the first cell division. Although DOCK8 mutant T cells underwent near-normal primary clonal expansion after primary infection with recombinant influenza virus in vivo, they showed greatly reduced memory cell persistence and recall. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells. |
| مصطلحات الفهرس: | Keywords: CD45RA antigen; chemokine receptor CCR7; lymphocyte function associated antigen 1; protein; protein dock8; unclassified drug; animal cell; animal experiment; animal model; animal tissue; article; CD8+ T lymphocyte; cell division; cell function; cell polar, Journal article |
| URL: | |
| الإتاحة: | Open access content. Open access content Author/s retain copyright |
| أرقام أخرى: | AUANP oai:openresearch-repository.anu.edu.au:1885/39046 0022-1007 1291772508 |
| المصدر المساهم: | AUSTRALIAN NAT UNIV - PRINT REPOSITORY From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1291772508 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |