التفاصيل البيبلوغرافية
| العنوان: |
The effect of intraoperative fluid administration on outcomes of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy |
| المؤلفون: |
Shamavonian, Raphael, McLachlan, Rohan, Fisher, Oliver M, Valle, Sarah J, Alzahrani, Nayef A, Liauw, Winston, Morris, David L |
| المصدر: |
Medical Papers and Journal Articles |
| بيانات النشر: |
ResearchOnline@ND |
| سنة النشر: |
2019 |
| المجموعة: |
The University of Notre Dame, Australia: ResearchOnline@ND |
| مصطلحات موضوعية: |
cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), intraoperative fluids (IOFs), Medicine and Health Sciences |
| الوصف: |
Background: Determine the effect of intraoperative fluids (IOFs) administered during cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on postoperative patient outcomes. Methods: Retrospective cohort study of patients that underwent CRS/HIPEC from February 2010 to June 2017. Results: A total of 335 patients formed the cohort study. Patients who received higher IOFs had longer hospital length of stay (LOS) (34 vs. 22.5 days; P<0.001), extended intensive care unit (ICU) admission (5.3 vs. 3.2 days; P<0.001) and a 12% increase in grade 3/4 complications (P<0.001). Greater amounts of blood product transfusion were associated with longer hospital LOS (33.7 vs. 23 days; P<0.001), and ICU admission (5 vs. 3.4 days; P<0.001) and 12% increase in grade 3/4 complications (P<0.001). When corrected for weight and peritoneal cancer index (PCI), increased transfusion of blood products still resulted in longer hospital LOS (31.2 vs. 25.2 days; P=0.04) and longer ICU admission (4.7 vs. 3.6 days; P=0.03). On multivariable analysis, less blood product transfusions demonstrated a decreased LOS in hospital by 4.8 days (P=0.01) and fewer grade 3/4 complications (OR 0.59; 95% CI, 0.35–0.99; P=0.05). Conclusions: Greater IOF administration is associated with an increase in postoperative morbidity, including hospital LOS, ICU admission and grade 3/4 complications, in patients undergoing CRS/HIPEC. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://researchonline.nd.edu.au/med_article/1029Test |
| الإتاحة: |
https://researchonline.nd.edu.au/med_article/1029Test |
| رقم الانضمام: |
edsbas.F06D1ECC |
| قاعدة البيانات: |
BASE |
