Prognosis Analysis of Patients with Pancreatic Neuroendocrine Tumors After Surgical Resection and the Application of Enucleation
| العنوان: | Prognosis Analysis of Patients with Pancreatic Neuroendocrine Tumors After Surgical Resection and the Application of Enucleation |
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| المؤلفون: | Yongyu Yang, Heping Kan, Junzhang Chen, Yuanhua Liu |
| المصدر: | World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-11 (2021) World Journal of Surgical Oncology |
| بيانات النشر: | Research Square Platform LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pancreatic neuroendocrine tumor (pNETs), medicine.medical_treatment, Enucleation, lcsh:Surgery, Neuroendocrine tumors, lcsh:RC254-282, 03 medical and health sciences, Pancreatectomy, 0302 clinical medicine, Surgical oncology, medicine, Humans, Surveillance, epidemiology, end results (SEER) database, Stage (cooking), Pathological, Neoplasm Staging, Retrospective Studies, Pancreatic duct, Prognostic factor, Proportional hazards model, business.industry, Research, lcsh:RD1-811, Prognosis, medicine.disease, Pancreaticoduodenectomy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Pancreatic Neoplasms, Survival Rate, Neuroendocrine Tumors, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Surgical resection, Female, 030211 gastroenterology & hepatology, Surgery, Radiology, business |
| الوصف: | Objective To investigate the prognostic factors of patients with pancreatic neuroendocrine tumor (pNETs) after surgical resection, and to analyze the value of enucleation for pNETs without distant metastasis that are well-differentiated (G1) and have a diameter ≤ 4 cm. Methods Data from pNET patients undergoing surgical resection between 2004 and 2017 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan–Meier analysis and log-rank testing were used for the survival comparisons. Adjusted HRs with 95% CIs were calculated using univariate and multivariate Cox regression models to estimate the prognostic factors. P Results This study found that female, cases diagnosed after 2010, and pancreatic body/tail tumors were protective factors for good survival, while histological grade G3, a larger tumor size, distant metastasis, AJCC 8th stage III-IV and age over 60 were independent prognostic factors for a worse OS/CSS. For the pNETs that were well-differentiated (G1) and had a tumor diameter ≤ 4 cm, the type of surgery was an independent factor for the long-term prognosis of this group. Compared with pancreaticoduodenectomy and total pancreatectomy, patients who were accepted enucleation had better OS/CSS. Conclusion For pNETs patients undergoing surgical resection, sex, year of diagnosis, tumor location, pathological grade, tumor size, distant metastasis, race, and age were independent prognostic factors associated with the OS/CSS of patients. For pNETs patients with G1 and a tumor diameter less than 4 cm, if the tumor was located over 3 mm from the pancreatic duct, enucleation may be a wise choice. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28fe40cecb71aba6a0204004b80d306Test https://doi.org/10.21203/rs.3.rs-98578/v1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b28fe40cecb71aba6a0204004b80d306 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |