Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
| العنوان: | Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 |
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| المؤلفون: | Farhadian, Shelli, Glick, Laura R., Vogels, Chantal B. F., Thomas, Jared, Chiarella, Jennifer, Casanovas-Massana, Arnau, Zhou, Jing, Odio, Camila, Vijayakumar, Pavithra, Geng, Bertie, Fournier, John, Bermejo, Santos, Fauver, Joseph R., Alpert, Tara, Wyllie, Anne L., Turcotte, Cynthia, Steinle, Matthew, Paczkowski, Patrick, Dela Cruz, Charles, Wilen, Craig, Ko, Albert I., MacKay, Sean, Grubaugh, Nathan D., Spudich, Serena, Barakat, Lydia Aoun |
| المصدر: | BMC neurology, 20(1):248 Research Square article-version (status) pre article-version (number) 1 BMC Neurology, Vol 20, Iss 1, Pp 1-5 (2020) BMC Neurology |
| بيانات النشر: | Research Square Platform LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurology, Pneumonia, Viral, Central nervous system, Encephalopathy, Case Report, Inflammation, Disease, lcsh:RC346-429, Article, neuroinflammation, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Altered Mental Status, Seizures, medicine, Humans, Neurochemistry, Encephalitis, Viral, Pandemics, lcsh:Neurology. Diseases of the nervous system, Neuroinflammation, Aged, 030304 developmental biology, 0303 health sciences, SARS-CoV-2, business.industry, COVID-19, General Medicine, medicine.disease, medicine.anatomical_structure, Acute Disease, Immunology, Cytokines, Female, Neurology (clinical), Neurosurgery, medicine.symptom, Presentation (obstetrics), Coronavirus Infections, business, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Conclusion Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614228232c76ac53640a84a1101df0aaTest https://doi.org/10.21203/rs.3.rs-28583/v1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....614228232c76ac53640a84a1101df0aa |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |