Standardized Aronia Melanocarpa Extract Regulates Redox Status In Patients Receiving Hemodialysis With Anemia

التفاصيل البيبلوغرافية
العنوان: Standardized Aronia Melanocarpa Extract Regulates Redox Status In Patients Receiving Hemodialysis With Anemia
المؤلفون: Nebojsa Andjelkovic, Sergey Bolevich, Jovana Jeremic, Ivan Srejovic, Miroslav Mitrovic, Vladimir Jakovljevic, Vladimir Zivkovic, Isidora Milosavljevic, Nevena Draginic, Vladislava Stojic, Dejan Petrovic
بيانات النشر: Research Square Platform LLC, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Male, medicine.medical_specialty, Antioxidant, Anemia, medicine.medical_treatment, Clinical Biochemistry, medicine.disease_cause, Gastroenterology, Antioxidants, chemistry.chemical_compound, Renal Dialysis, Internal medicine, Lactate dehydrogenase, parasitic diseases, Photinia, Medicine, Humans, Molecular Biology, Inflammation, biology, business.industry, Plant Extracts, Haptoglobin, Polyphenols, Cell Biology, General Medicine, Middle Aged, medicine.disease, Ferritin, Treatment Outcome, chemistry, biology.protein, Female, Hemodialysis, business, Oxidation-Reduction, Oxidative stress, Kidney disease
الوصف: The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After finishing the treatment blood samples were taken in order to evaluate the effects of SAE on redox status. Several parameters of anemia and inflammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites significantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by beneficial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn`t improve inflammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has beneficial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could potentially be a good choice for supplementation of anemic hemodialysis patients. TRN: NCT04208451 December 23, 2019 “retrospectively registered”
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca740bb82f61743646517f0a8b537e8Test
https://doi.org/10.21203/rs.3.rs-309012/v1Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....3ca740bb82f61743646517f0a8b537e8
قاعدة البيانات: OpenAIRE