المؤلفون: Guo-Rong Chen, Liang-Hong Yu, Pei-Sen Yao, Zhangya Lin, De-Zhi Kang, Xue-Ling Xie, Shu-Fa Zheng, Yuan-Xiang Lin, Haojie Wang, Huang-Cheng Shang-Guan

مصطلحات موضوعية: medicine.medical_specialty, Adverse outcomes, business.industry, Retrospective cohort study, Phosphate, Independent predictor, medicine.disease, Surgery, chemistry.chemical_compound, Microsurgical clipping, Aneurysm, chemistry, medicine, business, Serum lactate dehydrogenase

الوصف: Objective: We assessed the correlation between lactate dehydrogenase(LDH) to phosphate ratio and the prognosis of microsurgically clipping for ruptured intracranial aneurysm (rIA) in this study, to test the hypothesis that serum LDH to phosphate ratio could be a predictor for the outcome of microsurgically clipping for rIA. Methods: The rIA patients between 2012 and 2018 were retrospectively collected. Age, sex, Hunt-Hess(H-H) grade, Fisher grade, smoking, drink, medical history, aneurysm location, hydrocephalus, laboratory data including serum LDH, phosphate and LDH to phosphate ratio, related complication and the outcomes in 3 months were recorded. Results: A total of 1608 rIA patients in our institution were collected, and 856 patients treated by microsurgical clipping were enrolled. A significantly higher LDH- phosphate ratio on admission was observed in patients with poor outcome at 3 months (median±SD, 200.175±107.290 for mRS 0–2 vs 323.826±219.075 for mRS score 3–6; P Conclusions: LDH to phosphate ratio was a potential biomarker and could predict the unfavorable outcome of microsurgically clipping for rIA in 3 months. However, the detailed mechanism remain unclear and the conclusion needs be further confirmed by large-scale randomized clinical trials.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ef8f850f2c953779b7e92979b631c9ceTest
https://doi.org/10.21203/rs.3.rs-853165/v1Test

المؤلفون: Zhang Keming, Hu Dongying, Wanqing Liao, Jun Zou, Lei Zhang, Weihua Pan, Huang Yue, Hang Li

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Albumin, Gastroenterology, chemistry.chemical_compound, Cerebrospinal fluid, chemistry, Lactate dehydrogenase, Internal medicine, Hospital discharge, Medicine, In patient, business, Cryptococcal meningitis

الوصف: BackgroundCryptococcal meningitis (CM) is a life-threatening infection of the central nervous system that occurs in healthy individuals and immunocompromised patients, and reliable prognostic parameters are needed urgently. This study analyzed the clinical characteristics and laboratory findings of CM patients from two tertiary care hospitals in China between 2015 and 2019, aiming to provide reliable prognostic factors for patients with CM.MethodsClinical characteristics and laboratory findings of CM patients were retrospectively reviewed. The unfavorable outcome was defined as no improvement or worsening symptoms and signs or persistent positive results for CSF culture or death after starting treatment. The significant differences in clinical characteristics and symptoms between the patients with favorable and unfavorable outcomes were descriptively analyzed. For comparison of mean values of laboratory results between the patients with favorable and unfavorable outcomes, the t test was performed.Results63 patients with CM were enrolled in this study and 67% were men. 38/63 patients were confirmed to be HIV serology positive. The mean onset age of all patients was 49±15 (20– 77) years. For clinical characteristics, headache, nausea and/or vomiting, and fever were the most common symptoms. Older age and disturbance of consciousness tended to poor prognosis. Changes in serum antioxidant parameters were significantly associated with clinical outcome. For CSF parameters, there were significant correlations between changes in leukocyte count, lactate dehydrogenase and chloride, and outcomes in different groups. For HIV-infected patients, increased CD4+ T cell counts suggested good prognosis. Increased CSF/serum albumin quotient (Qalb) was indicative of unfavorable outcome in HIV-negative patients.ConclusionsIn summary, CSF lactate dehydrogenase and albumin quotient may improve prediction of outcome in patients with CM. We recommend incorporation of Qalb value analysis and pay attention to change of CSF LDH during hospitalization.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::80a00be461992f4e3428a51e87e0ecf5Test
https://doi.org/10.21203/rs.3.rs-789545/v1Test

المؤلفون: Reza Hajizadeh, Tooba Mohammadi, Hadiseh Kavandi, Samad Ghaffari, Sahar Ghodratizadeh, Mehdi Mohebalizadeh, K Mohammadi

مصطلحات موضوعية: In hospital death, medicine.medical_specialty, genetic structures, business.industry, medicine.disease, behavioral disciplines and activities, Gastroenterology, Pulmonary embolism, Text mining, Internal medicine, medicine, business, psychological phenomena and processes, Serum lactate dehydrogenase level

الوصف: Background: There are few studies evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed possible power of serum LDH level to predict in-hospital mortality. Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included. Results: The mean age of patients were 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however this association was not significant. Conclusions: In patients with pulmonary embolism, LDH can be a good prognostic marker for predicting in-hospital death.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aab28eae5f294a6c27cdb8ef7c44092Test
https://doi.org/10.21203/rs.3.rs-276184/v2Test

المؤلفون: Jun Leng Goh, Pradeep Paul George, Bee Hoon Heng, John Arputham Abisheganaden, Albert Yick Hou Lim, Mae Chui Wei Chua

المساهمون: Lee Kong Chian School of Medicine (LKCMedicine)

المصدر: BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-16 (2021)
BMC Pulmonary Medicine

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Neutrophil count, Neutrophils, Lymphocyte, Temporal trends, Disease, SARS-COV-2, Severity of Illness Index, 030218 nuclear medicine & medical imaging, C-reactive protein, 03 medical and health sciences, chemistry.chemical_compound, Leukocyte Count, 0302 clinical medicine, Internal medicine, Lactate dehydrogenase, Lymphopenia, Severity of illness, Medicine, Humans, Medicine [Science], 030212 general & internal medicine, Lung, lcsh:RC705-779, biology, L-Lactate Dehydrogenase, business.industry, CT thorax imaging, COVID-19, Pneumonia, lcsh:Diseases of the respiratory system, medicine.disease, Clinical manifestations, medicine.anatomical_structure, chemistry, biology.protein, Absolute neutrophil count, Disease Progression, Lymphocyte count, business, Research Article

الوصف: Background COVID-19 is a systemic viral infection which mainly targets the human respiratory system with many secondary clinical manifestations especially affecting the hematopoietic system and haemostasis. Few studies have highlighted the prognostic value of blood findings such as lymphopenia, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, LDH, CRP, cardiac troponin, low-density lipoproteins and chest radiographic abnormality. A study of progressions of blood and radiological results may help to identify patients at high risk of severe outcomes. This systematic review aimed to assess the temporal progression of blood and radiology findings of patients with COVID-19. Methods Comprehensive systematic literature search was conducted on Medline, Embase and Cochrane databases to identify articles published for peripheral blood investigation and radiological results of COVID-19 patients. Results A total of 27 studies were included in this review. The common laboratory features reported include lymphopenia, elevated levels of C-reactive proteins and lactate dehydrogenase. For radiological signs, ground-glass opacifications, consolidations, and crazy paving patterns were frequently reported. There is a correlation between lymphocyte count, neutrophil count and biomarkers such as C-reactive proteins and lactate dehydrogenase; at a later phase of the disease (more than 7 days since onset of symptoms), lymphopenia worsens while neutrophil count, C-reactive protein levels and lactate dehydrogenase levels increase. Frequencies of ground-glass opacifications and ground-glass opacifications with consolidations decrease at a later phase of the disease while that of consolidation and crazy paving pattern rises as the disease progresses. More extensive lung involvement was also seen more frequently in the later phases. Conclusion The correlation between temporal progression and the reported blood and radiological results may be helpful to monitor and evaluate disease progression and severity.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5935d6f4183146718621778b51dd489aTest
https://doi.org/10.21203/rs.3.rs-62902/v1Test

المؤلفون: Kamil Pehlivanoglu, Ferda Keskin Cimen, Halis Suleyman, Nezahat Kurt, Bahadir Suleyman, Eray Kurnaz, Aslı Özbek Bilgin, Renad Mammadov, Huseyin Eken, Arif Burak Cekic, Orhan Cimen

المصدر: BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-9 (2020)

مصطلحات موضوعية: Male, Antioxidant, medicine.medical_treatment, Injury, Pharmacology, Antioxidants, chemistry.chemical_compound, 0302 clinical medicine, Malondialdehyde, Pharmacology (medical), Group level, Glutathione Transferase, 0303 health sciences, biology, virus diseases, Alanine Transaminase, Liver ischemia, Glutathione, Drug Combinations, Glutathione Reductase, Liver, 030220 oncology & carcinogenesis, Myeloperoxidase, Reperfusion Injury, Research Article, Liv-52, Ischemia, Superoxide dismutase, 03 medical and health sciences, lcsh:RA1190-1270, Lactate dehydrogenase, medicine, Animals, Aspartate Aminotransferases, Rats, Wistar, 030304 developmental biology, lcsh:Toxicology. Poisons, Peroxidase, Glutathione Peroxidase, L-Lactate Dehydrogenase, business.industry, Plant Extracts, Superoxide Dismutase, lcsh:RM1-950, medicine.disease, Ischemia reperfusion, lcsh:Therapeutics. Pharmacology, chemistry, biology.protein, Rat, business

الوصف: Background Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats. Methods Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals. Results Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically. Conclusions Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b511f1c6215aa67e8c9e8973439835Test
https://doi.org/10.21203/rs.2.14473/v3Test

المؤلفون: Nebojsa Andjelkovic, Sergey Bolevich, Jovana Jeremic, Ivan Srejovic, Miroslav Mitrovic, Vladimir Jakovljevic, Vladimir Zivkovic, Isidora Milosavljevic, Nevena Draginic, Vladislava Stojic, Dejan Petrovic

مصطلحات موضوعية: Male, medicine.medical_specialty, Antioxidant, Anemia, medicine.medical_treatment, Clinical Biochemistry, medicine.disease_cause, Gastroenterology, Antioxidants, chemistry.chemical_compound, Renal Dialysis, Internal medicine, Lactate dehydrogenase, parasitic diseases, Photinia, Medicine, Humans, Molecular Biology, Inflammation, biology, business.industry, Plant Extracts, Haptoglobin, Polyphenols, Cell Biology, General Medicine, Middle Aged, medicine.disease, Ferritin, Treatment Outcome, chemistry, biology.protein, Female, Hemodialysis, business, Oxidation-Reduction, Oxidative stress, Kidney disease

الوصف: The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After finishing the treatment blood samples were taken in order to evaluate the effects of SAE on redox status. Several parameters of anemia and inflammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites significantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by beneficial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn`t improve inflammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has beneficial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could potentially be a good choice for supplementation of anemic hemodialysis patients. TRN: NCT04208451 December 23, 2019 “retrospectively registered”

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca740bb82f61743646517f0a8b537e8Test
https://doi.org/10.21203/rs.3.rs-309012/v1Test

المؤلفون: Luping Zhang, Yingli Zhang, Nan Zhang, Tantan Ma, Fengming Ni, Xiaoming Xu, Mingqing Liu, Hong Xu

مصطلحات موضوعية: medicine.medical_specialty, chemistry.chemical_compound, Coronavirus disease 2019 (COVID-19), chemistry, business.industry, Internal medicine, Lactate dehydrogenase, medicine, Albumin, In patient, business, Predictive value, Gastroenterology

الوصف: BackgroundCoronavirus Disease-2019 (COVID-19) is an emerging acute infectious disease that was first discovered in Wuhan, Hubei Province, China. Since then, it has quickly spread to over one hundred cities around the world. Therefore, it is crucial to identify the risk factors of in-hospital mortality and disease severity for COVID-19 patients. MethodsWe firstly proposed a biomarker ratio, lactate dehydrogenase(LDH) to albumin ratio (LAR) may be more reliable to assess the predictive value of LAR for in-hospital mortality and early identification of critical COVID-19 patients. A retrospective study was conducted including patients (≥18 years old) with laboratory-confirmed COVID-19 infection who had been discharged or had died from 1 February to 29 February, 2020. ResultsThe study included 321 patients with COVID-19. The median age of the 321 patients was 63.0 (IQR 51.0-70.0), ranging from 19 to 95 years old and 180 (56.1%) patients were male. 142 (44.2%) patients had 1 or more coexisting comorbidity. The most common symptoms on admission were fever(289[90%]) and cough(258[80.4%]). In multivariable logistic regression, only older age (OR, 1.11; 95% CI, 1.05-1.16), WBC count (OR, 1.26; 95% CI, 1.11-1.44), lymphocyte count (OR, 0.78; 95% CI, 0.62-0.99) and LAR (OR, 1.29; 95% CI, 1.18-1.40) were found to be significantly associated with in-hospital death. ROC analysis showed that LAR had a higher AUC (0.917) and the highest specificity(84.0%) and sensitivity(84.6%). Furthermore, the results showed that LAR had a higher AUC (0.931) to differentiate critical from mild patients and had a sensitivity of 87.7% and a specificity of 82.1%. Besides, LAR had an AUC (0.861) to differentiate critical from severe patients and had a sensitivity of 86.0% and a specificity of 73.8% and the role of LAR to distinguish severe from mild patients was the worst. ConclusionsTo the best of our knowledge, this study is the first for us to explore the predictive value of LAR for in-hospital mortality and disease severity. A high LAR appears to predict higher odds of mortality and differentiate critical patients from mild or severe COVID-19 patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a206e1fa018d524cb7bb0928560940dTest
https://doi.org/10.21203/rs.3.rs-143788/v1Test

المؤلفون: Jiahui Zhang, Jinfeng Wu, Wei Ji, Yongdong Yan, Zhichao Sun, Li Huang, Zhengrong Chen, Rongrong Li, Ting Wang, Jiahong Tan

المصدر: BMC Infectious Diseases
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)

مصطلحات موضوعية: Male, Mycoplasma pneumoniae, Neutrophils, Mucus plug, medicine.disease_cause, Gastroenterology, 0302 clinical medicine, Adrenal Cortex Hormones, Risk Factors, Prealbumin, 030212 general & internal medicine, Child, Children, Univariate analysis, Infectious Diseases, C-Reactive Protein, Child, Preschool, Female, medicine.symptom, Research Article, medicine.medical_specialty, Mycoplasma pneumoniae pneumonia, Fever, Bronchial mucus, Bronchi, lcsh:Infectious and parasitic diseases, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, 030225 pediatrics, Internal medicine, Bronchoscopy, Pneumonia, Mycoplasma, medicine, Humans, lcsh:RC109-216, Risk factor, Retrospective Studies, L-Lactate Dehydrogenase, business.industry, Infant, Odds ratio, Length of Stay, medicine.disease, Mucus, Pneumonia, Logistic Models, ROC Curve, Sputum, business

الوصف: Background Recently, many cases of pneumonia in children with Mycoplasma pneumoniae infection have been shown to have varying degrees of intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of patients with Mycoplasma infection are analyzed in this study. The risk factors for M. pneumoniae pneumonia (MPP) mucus plug formation in children are explored, and a risk factor scoring system is established. Methods MPP patients treated with bronchoscopy were retrospectively enrolled in the study from February 2015 to December 2019. The children were divided into a mucus plug group and a control group according to the presence or absence of mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of the two groups of children were compared. Univariate and multivariate logistic regression models were used to identify the risk factors for MPP mucus plug formation. The receiver operating characteristic (ROC) curve was drawn to evaluate the regression model and establish the MPP mucous plug risk factor scoring system. Results A univariate analysis showed that the children in the mucous group were older and had a longer fever duration, longer hospital stay, higher fever peak, more cases of wheezing symptoms and allergies, and azithromycin or corticosteroids were administered later. In addition, neutrophil, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), sputum MP-DNA copy number, and total immunoglobulin A (IgA) levels were higher, while prealbumin (PA) levels were lower. The ROC curve analysis showed that children with MPP had PA ≤144.5 mg/L, had used corticosteroids during the course of the illness of ≥4.5 days, CRP ≥12.27 mg/L, an LDH ≥ 462.65 U/L, and there was a possibility of intra-airway mucus formation. The independent risk factors were scored according to their odds ratio (OR) value. Among the 255 children with MPP, the high-risk group had 44 (83.02%) mucus plugs out of 53; the middle-risk group had 35 (34.3%) mucus plugs out of 102; and the low-risk group had 11 (11%) mucus plugs out of 100. Conclusions PA levels, timing of corticosteroid use (use in the first few days), CRP levels, and LDH levels were independent risk factors for MPP mucus plug formation. This provides a basis for the early identification of MPP in children combined with mucus plug formation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd21c1410001c4467a4bd7df9fa246cTest
https://doi.org/10.21203/rs.3.rs-54708/v3Test

المؤلفون: Kaijin Wang, Jiancheng Xu, Xuetong Zhu, Qi Zhou

المصدر: BMC Pediatrics, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Pediatrics

مصطلحات موضوعية: Adult, Male, Analyte, China, Population, Physiology, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Reference Values, Lactate dehydrogenase, Medicine, Humans, education, Child, education.field_of_study, Creatinine, Sex Characteristics, biology, business.industry, Infant, Newborn, Reference intervals, lcsh:RJ1-570, Gestational age, Infant, Neonates, lcsh:Pediatrics, Delivery mode, Biochemical analytes, Lipids, Enzymes, chemistry, 030220 oncology & carcinogenesis, Child, Preschool, Pediatrics, Perinatology and Child Health, Multivariate Analysis, biology.protein, Uric acid, Regression Analysis, Creatine kinase, Female, business, Research Article

الوصف: Background Biochemical analytes provide information for neonatal disease management and therapy, and population-based reference intervals (RIs) are essential to accurately interpret laboratory test results. This study aimed to establish local RIs for biochemical assays in term neonates. Methods A total of 195 healthy term neonates from birth to 3rd day were recruited as reference individuals prospectively. Analytes of 26 common biochemistries were measured using the VITROS 5600 Integrated System. The 3-level nested ANOVA was performed to assess the need for partitioning RIs of each analyte, and RIs were derived by a nonparametric method or robust method. Multiple regression analysis was used to evaluate specific correlations between the analytes and individual characteristics including age, gender, gestational age, birthweight and delivery mode. Results There were no between-sex differences in all analytes, whereas there were significant between-day-age differences in 6 analytes. Small between-delivery-mode differences were observed in the results for potassium, phosphorus, and urea. The major related factor of most analytes was postnatal age. During the first 3 days, values of iron, lipids and lipoproteins increased; creatinine, urea, uric acid, creatine kinase and lactate dehydrogenase decreased; other analytes showed slight changes or relatively stable trends. Reference limits of some analytes, particularly lactate dehydrogenase and alkaline phosphatase, were significantly different from adult and pediatric groups. Conclusions RIs of 26 common biochemical analytes are established for term neonates aged 0 to 3 days in northeast China. Additionally, it is suggested that age-related changes should be valued in the clinical decision-making process for newborns.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96216b634110cf62941d2d6d45057530Test
https://doi.org/10.21203/rs.3.rs-113250/v1Test

المؤلفون: Yuxian Huang, Hongyu Wang, Wenhong Zhang, Xian Zhou, Taoping Weng, Yang Li, Haocheng Zhang, Jing-Wen Ai

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Coronavirus disease 2019 (COVID-19), business.industry, Lactate dehydrogenase, Immunology, Case-control study, Medicine, business

الوصف: Introduction Coronavirus disease 2019 (COVID-19) is now officially a pandemic. Current studies observed extensive abnormal indexes in COVID-19 patients and significant differences between mild and severe patients. However, which index would perform better as the indicator of disease progression merits further investigation.Methods We enrolled COVID-19 patients who were admitted to Shanghai Public Health Clinical center. We closely monitored the following candidate indictors: white blood cell, lymphocyte, platelet, CD4 T cell, CD8 T cell, alanine aminotransferase, estimated glomerular filtration rate (eGFR), fibrin degradation products (FDP), D-dimer, creatine kinase, myoglobin, troponin T (TnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), lactase dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin. The correlation with illness severity were assessed by Spearman analysis and the ability of differentiating the clinical statuses was quantified as the AUC value of the ROC curve. Results A total of 326 patients were enrolled, including 299 mild-ordinary and 27 severe-critical patients. At admission, D-dimer and CRP were elevated above normal range both in mild-ordinary and severe-critical patients. LDH, NT-proBNP, myoglobin, CD4 T cell, eGFR, FDP and PCT were beyond normal range in the mild-ordinary stages of severe-critical patients, but remained normal in the persistently mild-ordinary patients. Top 5 parameters with highest spearmen coefficient were LDH, procalcitonin, NT-proBNP, myoglobin and D-dimer (Spearman coefficient: 0.488, 0.453, 0.414, 0.412, 0.407). Comparing between mild-ordinary stage and severe/critical stage, LDH showed the highest receiver operating characteristics (ROC) area under the curve (AUC) of 0.951. PCT ranked second, with the ROC AUC of 0.905. Comparing between mild-ordinary and severe stages, only LDH had the ROC AUC of over 0.90 (0.927). Conclusions This study found LDH to be a superior indicator for COVID-19 status and had the potential to optimize the clinical management strategy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6786ba0df331e55d9937feb8f2104dbaTest
https://doi.org/10.21203/rs.3.rs-55590/v1Test