The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study
| العنوان: | The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study |
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| المؤلفون: | Hassan Kahal, Abd A. Tahrani, Nathan W P Cantley, Kathryn Lonnen, Ioannis Kyrou |
| المصدر: | BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021) BMC Endocrine Disorders |
| بيانات النشر: | Research Square Platform LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Population, Overweight, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, Insulin resistance, Weight loss, Diabetes mellitus, Internal medicine, Prevalence, medicine, Humans, Obesity, education, Type 1 diabetes, education.field_of_study, business.industry, Research, nutritional and metabolic diseases, General Medicine, Middle Aged, Type 1 Diabetes Mellitus, Prognosis, RC648-665, medicine.disease, United Kingdom, Double diabetes, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, medicine.symptom, business, Biomarkers, Follow-Up Studies |
| الوصف: | Background Double Diabetes (DD), type 1 diabetes (T1DM) + insulin resistance (IR), is associated with increased risk of micro/macro-vascular complications and mortality. Obesity can contribute to the development of DD. This study explored the prevalence of overweight/obesity and their association with DD in adults with T1DM. Methods Cross-sectional study of consecutive adults with T1DM attending diabetes clinics in a secondary care hospital (January-November 2019). Estimated glucose disposal rate (eGDR) was used as a marker of IR, and an eGDR Results One hundred seven adults with T1DM were included; female/male: 51/56; age [median (inter-quartile range): 30.0 (23–51) years]; BMI 25.4 (22.8–30.0) kg/m2. Overweight/obesity prevalence was 57/107 (53.3 %) [overweight: 30/107 (28 %); obesity: 27/107 (25.2 %)]. Compared to those with normal BMI, individuals with T1DM and overweight/obesity had longer diabetes duration; higher total daily insulin dose; and higher DD prevalence: 48/57 (84.2 %) vs. 14/50 (28 %) (p Conclusions Overweight/obesity is very common in adults with T1DM, and is associated with double diabetes. BMI is positively associated with total insulin dose. Double diabetes is associated with adverse cardiovascular risk profile and is also common in lean individuals with T1DM. Further research is needed to examine the impact of overweight/obesity in people with T1DM and whether weight loss in this population can improve diabetes-related outcomes. |
| وصف الملف: | application/pdf |
| تدمد: | 1472-6823 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90bb781795562c949cee35dc79bdf1eTest https://doi.org/10.21203/rs.3.rs-256189/v1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c90bb781795562c949cee35dc79bdf1e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14726823 |
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