Evaluation of Clinical Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma via Bioinformatics
| العنوان: | Evaluation of Clinical Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma via Bioinformatics |
|---|---|
| المؤلفون: | Yongxiang Song, Wendong Qu, Qingyong Cai, Xu Han, Xixian Ke, Cheng Chen, Gang Xu, Jiebin Zuo, Yang Tang |
| المصدر: | BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021) BMC Cancer |
| بيانات النشر: | Research Square Platform LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Lung adenocarcinoma, Cancer Research, Lung Neoplasms, Bioinformatics, Datasets as Topic, Adenocarcinoma of Lung, Kaplan-Meier Estimate, Biology, BUB1B, Disease-Free Survival, Mitochondrial Proteins, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Genetics, medicine, Biomarkers, Tumor, Humans, KEGG, Lung, Survival analysis, RC254-282, Aged, Neoplasm Staging, Aged, 80 and over, Cyclin-dependent kinase 1, MTFR2, Research, Gene Expression Profiling, Computational Biology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Biomarker, Cell cycle, Middle Aged, medicine.disease, Prognosis, Up-Regulation, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Adenocarcinoma, Biomarker (medicine), Female, Neoplasm Recurrence, Local |
| الوصف: | Background Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported. Herein, this study analyzed the clinical significance and potential mechanisms of MTFR2 in LUAD via bioinformatics tools. Results We found that the level of MTFR2 was increased, and correlated with sex, age, smoking history, neoplasm staging, histological subtype and TP53 mutation status in LUAD patients. Kaplan-Meier survival analysis showed LUAD patients with increased MTFR2 had a poor prognosis. In addition, univariate COX regression analysis showed neoplasm staging, T stage, distant metastasis and MTFR2 level were risk factors for the prognosis of LUAD. A total of 1127 genes were coexpressed with MTFR2, including 840 positive and 208 negative related genes. KEGG and GSEA found that MTFR2 participated in the progression of LUAD by affecting cell cycle, DNA replication, homologous recombination, p53 signaling pathway and other mechanisms. The top 10 coexpressed genes, namely CDK1, CDC20, CCNB1, PLK1, CCNA2, AURKB, CCNB2, BUB1B, MAD2L1 and BUB1 were highly expressed, and were associated with poor prognosis in LUAD. Conclusions Consequently, we elucidated MTFR2 was a biomarker for diagnosis and poor prognosis in LUAD, and might participate in the progression of LUAD via affecting cell cycle, DNA replication, homologous recombination and p53 signaling pathway. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2af2899dd1d84c5215154d50e75fc7Test https://doi.org/10.21203/rs.3.rs-132516/v1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9f2af2899dd1d84c5215154d50e75fc7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |