Nephrotoxicity of Iopamidol in Pediatric, Adolescent, and Young Adult Patients Who Have Undergone Allogeneic Bone Marrow Transplantation
| العنوان: | Nephrotoxicity of Iopamidol in Pediatric, Adolescent, and Young Adult Patients Who Have Undergone Allogeneic Bone Marrow Transplantation |
|---|---|
| المؤلفون: | Sue C. Kaste, Olga Goloubeva, Laura C. Bowman, Xiaoping P. Xiong, Ann E. Haight |
| المصدر: | Radiology. 226:399-404 |
| بيانات النشر: | Radiological Society of North America (RSNA), 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Urology, Contrast Media, Renal function, Kidney, Iopamidol, Blood Urea Nitrogen, Nephrotoxicity, chemistry.chemical_compound, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Child, Blood urea nitrogen, Bone Marrow Transplantation, Retrospective Studies, Creatinine, business.industry, Infant, medicine.disease, Surgery, medicine.anatomical_structure, chemistry, Child, Preschool, Female, Kidney Diseases, Bone marrow, Tomography, X-Ray Computed, business, Complication, Immunosuppressive Agents, Kidney disease, medicine.drug |
| الوصف: | To assess the effects of the low-osmolar contrast agent iopamidol and antimicrobial drugs on renal function in pediatric, adolescent, and young adult patients who have undergone bone marrow transplantation (BMT).A retrospective review of records of 120 consecutive pediatric patients who underwent allogeneic BMT in 1997 or 1998 was performed. Eighty-nine patients (median age, 8.1 years) fulfilled study eligibility criteria. Cumulative doses of nephrotoxic antimicrobial drugs were recorded, as well as serum creatinine and blood urea nitrogen concentrations from 24 hours before to 72 hours after each administration of iopamidol during a computed tomographic examination performed within 100 days after BMT. Random coefficient models were used to estimate nephrotoxic effects.Mean baseline glomerular filtration rate was 130.2 mL/min/1.73 m(2), and mean baseline creatinine concentration was 0.51 mg/dL (45 micro mol/L). Older age at BMT (P.001), use of foscarnet (P =.003), and receipt of iopamidol (P =.073) each prompted a rise in serum creatinine concentration. The antiviral drug foscarnet was associated with the largest increase in the creatinine level; the use of iopamidol effected a relatively small rise in creatinine level.Iopamidol nephrotoxicity was negligible in this cohort of pediatric patients who had undergone allogeneic BMT, even in the presence of elevated renal function levels. |
| تدمد: | 1527-1315 0033-8419 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211f297287524d0bc8596fbcb156fa76Test https://doi.org/10.1148/radiol.2262011471Test |
| رقم الانضمام: | edsair.doi.dedup.....211f297287524d0bc8596fbcb156fa76 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15271315 00338419 |
|---|