دورية أكاديمية
Unveiling a novel entry gate: Insect foregut as an alternative infection route for fungal entomopathogens.
| العنوان: | Unveiling a novel entry gate: Insect foregut as an alternative infection route for fungal entomopathogens. |
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| المؤلفون: | Lai, Yiling, Zheng, Weilu, Zheng, Yitong, Lu, Haiquan, Qu, Shuang, Wang, Lili, Li, Muwang, Wang, Sibao |
| المصدر: | Innovation (Camb) ; ISSN:2666-6758 ; Volume:5 ; Issue:4 |
| بيانات النشر: | PubMed Central |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Insects and their natural microbial pathogens are intertwined in constant arms races, with pathogens continually seeking entry into susceptible hosts through distinct routes. Entomopathogenic fungi are primarily believed to infect host insects through external cuticle penetration. Here, we report a new variety, Beauveria bassiana var. majus (Bbm), that can infect insects through the previously unrecognized foregut. Dual routes of infection significantly accelerate insect mortality. The pH-responsive transcription factor PacC in Bbm exhibits rapid upregulation and efficient proteolytic processing via PalC for alkaline adaptation in the foregut. Expression of PalC is regulated by the adjacent downstream gene Aia. Compared to non-enteropathogenic strains such as ARSEF252, Aia in Bbm lacks a 249-bp fragment, resulting in its enhanced alkaline-induced expression. This induction promotes PalC upregulation and facilitates PacC activation. Expressing the active form of BbmPacC in ARSEF252 enables intestinal infection. This study uncovers the pH-responsive Aia-PalC-PacC cascade enhancing fungal alkaline tolerance for intestinal infection, laying the foundation for developing a new generation of fungal insecticides to control destructive insect pests. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.xinn.2024.100644Test; https://pubmed.ncbi.nlm.nih.gov/38933340Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11201351Test/ |
| DOI: | 10.1016/j.xinn.2024.100644 |
| الإتاحة: | https://doi.org/10.1016/j.xinn.2024.100644Test https://pubmed.ncbi.nlm.nih.gov/38933340Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11201351Test/ |
| حقوق: | © 2024 The Author(s). |
| رقم الانضمام: | edsbas.E841DB2B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.xinn.2024.100644 |
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