25(ОН)D level, 10-year probability of major osteoporotic fractures, bone mineral density and quality, fat and lean mass in pre- and postmenopausal women
| العنوان: | 25(ОН)D level, 10-year probability of major osteoporotic fractures, bone mineral density and quality, fat and lean mass in pre- and postmenopausal women |
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| المؤلفون: | V.V. Povoroznyuk, O.S. Ivanyk |
| المصدر: | Mìžnarodnij Endokrinologìčnij Žurnal, Vol 16, Iss 3, Pp 194-203 (2020) |
| بيانات النشر: | Publishing House Zaslavsky, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:RC648-665, 10-year probability of major osteoporotic fractures, 25(он)d, total fat mass, osteoporosis, lcsh:Diseases of the endocrine glands. Clinical endocrinology |
| الوصف: | Background. Postmenopausal osteoporosis is an issue of great concern as it results in an elevated risk of fractures with a further negative impact on the elderly women’s health. The osteoporosis may be diagnosed based on the low-energy fractures occurring with no major trauma, or based on the low bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). The purpose of study is to examine 25(ОН)D level, 10-year probability of major osteoporotic fractures, bone mineral density and quality, fat and lean mass and to analyze their associations in the pre- and postmenopausal women. Materials and methods. Three hundred and two women aged 45–80 years (mean age — 61.3 ± 7.7 years) were examined and divided into 6 groups according to the pre- and postmenopausal period duration: group I — premenopausal women (n = 36; mean age — 50.1 ± 3.4 years); groups II–VI — postmenopausal women (n = 266; mean age — 62.8 ± 6.8 years). All the examined patients were subjected to bone mineral density measurement by the DXA on Prodigy system (GE Medical Systems, model 8743, 2005) according to the standard protocol. BMD and T-score of the lumbar spine, femoral neck and total skeleton were evaluated. Trabecular bone score of lumbar spine was measured by TBS iNsight (Med-Imaps, Pessac, France). Total 25(ОН)D was assessed by electrochemoluminescent method using Еlecsys 2010 analyzer (Roche Diagnostics, Germany) and Cobas test systems. The 10-year probability of major osteoporotic fractures and hip fractures was calculated by the Ukrainian FRAX model without DXA results considered. Total body fat and lean mass was assayed by the dual-energy X-ray absorptiometry (Prodigy, GE). Results. We found a significant association between the pre- and postmenopausal period duration and bone density and quality variables (trabecular bone score (F = 6.85; p |
| اللغة: | English |
| تدمد: | 2307-1427 2224-0721 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doajarticles::f4d6002e019b47a6189605bd9204658cTest http://iej.zaslavsky.com.ua/article/view/205266Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doajarticles..f4d6002e019b47a6189605bd9204658c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23071427 22240721 |
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