Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection
| العنوان: | Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection |
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| المؤلفون: | Andrea De Gottardi, Enos Bernasconi, Andreas Cerny, Alessandro Ceschi, Pietro Gianella, Raffaela Bertoli, Corneliu Fratila, Pietro Majno-Hurst, Gianluca Vanini, Lorenzo Magenta |
| المصدر: | Clinics and Research in Hepatology and Gastroenterology |
| بيانات النشر: | Published by Elsevier Masson SAS., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus-2, Cirrhosis, hydroxychloroquine, ALT, Alanine Aminotransferase, medicine.medical_treatment, Cefepime, Population, Liver transplantation, Gastroenterology, low-dose CT scan, Article, AST, Aspartate Aminotransferase, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, PCR, Polymerase Chain Reaction, education, education.field_of_study, BP, Blood Pressure, immunosuppression, Hepatology, business.industry, HR, Heart Rate, virus diseases, COVID-19, Hydroxychloroquine, Immunosuppression, Lopinavir, NASH, Non-Alcoholic Steatohepatitis, medicine.disease, lopinavir, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, HCV, Hepatitis C Virus, 030211 gastroenterology & hepatology, GGT, Gamma Glutamyl-Transferase, business, COVID-19, CoronaVirus Disease 19, medicine.drug |
| الوصف: | SUMMARY We present here the case of a 62-year-old man, who was referred to the emergency department with fever and cough for 3 days. He underwent liver transplantation 4 years earlier due to HCV and NASH-related cirrhosis with hepatocellular carcinoma. At admission he was in reduced general conditions. Nasopharyngeal smear specimen resulted positive for SARS-CoV-2 infection. Pulmonary low-dose CT-scan revealed bilateral subpleural ground-glass infiltrates. O2 saturation was 93%. A treatment with lopinavir/ritonavir and hydroxychloroquine twice daily was started. The patient received also cefepime and remained in isolation. Seven days later imaging showed a progression of the pulmonary infiltrates. Cefepime was replaced by meropenem. During the following 3 days the fever resolved, and the general conditions of the patient significantly improved. Consequently, treatment with lopinavir/ritonavir and hydroxychloroquine was stopped. The evolution of SARS-CoV-2 interstitial pneumonia in this immunosuppressed patient was moderate to severe and liver injury was not clinically significant. Despite its limitations, this case report confirm that the liver may be only mildly affected during SARS-CoV-2 infection, also in liver transplanted patients. Further studies are needed to assess whether the outcome of SARS-CoV-2 infection is worse in immunosuppressed patients than in the general population. |
| اللغة: | English |
| تدمد: | 2210-741X 2210-7401 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aa8ce08e6da3ef1832cc243234197aTest http://europepmc.org/articles/PMC7284277Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59aa8ce08e6da3ef1832cc243234197a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2210741X 22107401 |
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