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Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years.

التفاصيل البيبلوغرافية
العنوان: Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years.
المؤلفون: Dratva, Julia, Zemp, Elisabeth, Dharmage, Shyamali C, Accordini, Simone, Burdet, Luc, Gislason, Thorarinn, Heinrich, Joachim, Janson, Christer, Jarvis, Deborah, de Marco, Roberto, Norbäck, Dan, Pons, Marco, Real, Francisco Gómez, Sunyer, Jordi, Villani, Simona, Probst-Hensch, Nicole, Svanes, Cecilie
المساهمون: 1 Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland 2 Univ Basel, Basel, Switzerland 3 Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Melbourne, Vic 3010, Australia 4 Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy 5 Hop Intercantonal Broye, Payerne, Switzerland 6 Landspitali Univ, Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland 7 Helmholtz Ctr Munich, Natl Res Ctr Environm Hlth, Munich, Germany 8 Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany 9 German Ctr Lung Res DZ, Munich, Germany 10 Uppsala Univ, Dept Med Sci Resp Med & Allergol, Uppsala, Sweden 11 Univ London Imperial Coll Sci Technol & Med, Dept Publ Hlth Sci, London, England 12 Uppsala Univ, Dept Med Sci Occupat Environm Med, Uppsala, Sweden 13 Reg Hosp Lugano, Div Pulm Med, Lugano, Switzerland 14 Univ Bergen, Dept Clin Sci, Bergen, Norway 15 Haukeland Hosp, Dept Obstet & Gynaecol, N-5021 Bergen, Norway 16 Ctr Res Environm Epidemiol CREAL, Barcelona, Spain 17 Univ Pavia, Fac Med, Dept Publ Hlth Neurosci Expt & Legal Med, Via Palestro 3, I-27100 Pavia, Italy 18 Univ Bergen, Ctr Int Hlth, Bergen Resp Res Grp, Bergen, Norway 19 Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway
بيانات النشر: Public Library Science
سنة النشر: 2016
المجموعة: Hirsla - Landspítali University Hospital research archive
مصطلحات موضوعية: Lungnasjúkdómar, Umhverfisáhrif, Reykingar, Asma, Börn, Foreldrar, PAD12, Lung, Life Style, Pulmonary Disease, Chronic Obstructive, Smoking/adverse effects, Asthma, Age of Onset
الوصف: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. ; Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied. ; Spirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression. ; Early life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age. ; Early life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further. ; Swiss National Science Foundation PMPDP3_129021/1 PMPDP3_141671/1 Lung league Beider Basel, Lung league Graubunden Stiftung ehemals Bundner Heilstatten COST action BM1201 SAPALDIA ECRHS
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1932-6203
العلاقة: http://dx.doi.orgTest/ 10.1371/journal.pone.0145127; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728209Test/; PLoS ONE 2016, 11 (1):e0145127; http://hdl.handle.net/2336/606069Test; PloS one
DOI: 10.1371/journal.pone.0145127
الإتاحة: https://doi.org/10.1371/journal.pone.0145127Test
http://hdl.handle.net/2336/606069Test
حقوق: Archived with thanks to PloS one ; Open Access
رقم الانضمام: edsbas.51C2AAC0
قاعدة البيانات: BASE
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0145127