The biochemical anatomy of cortical inhibitory synapses
| العنوان: | The biochemical anatomy of cortical inhibitory synapses |
|---|---|
| المؤلفون: | Julio Santos-Torres, Brian T. Chait, Nathaniel Heintz, John C. Earnheart, Fekrije Selimi, Inés Ibañez-Tallon, Wenzhu Zhang, Elizabeth A. Heller, Chiye Aoki, Marta A. Ślimak |
| المصدر: | PLoS ONE, Vol 7, Iss 6, p e39572 (2012) PLoS ONE |
| بيانات النشر: | Public Library of Science (U.S.A.), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Proteomics, Anatomy and Physiology, Xenopus, Neurophysiology, Nonsynaptic plasticity, lcsh:Medicine, Mice, Transgenic, Nerve Tissue Proteins, Biology, Biochemistry, Mass Spectrometry, Neurological System, Mice, 03 medical and health sciences, 0302 clinical medicine, Synaptic augmentation, Metaplasticity, Animals, Humans, lcsh:Science, 030304 developmental biology, Cerebral Cortex, 0303 health sciences, Multidisciplinary, Synaptic scaling, Synaptic pharmacology, lcsh:R, Neural Inhibition, Neurochemistry, Anatomy, Gamma-Aminobutyric Acid, Receptors, GABA-A, Cell biology, Protein Transport, HEK293 Cells, Synaptic fatigue, Synapses, Synaptic plasticity, Medicine, lcsh:Q, Neurochemicals, Molecular Neuroscience, Function and Dysfunction of the Nervous System, Postsynaptic density, 030217 neurology & neurosurgery, Research Article, Neuroscience |
| الوصف: | Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have established the paradigm of the synapse as a complex signal-processing machine that controls synaptic plasticity. We report here the results of a proteomic analysis of type 2, inhibitory synaptic complexes isolated by affinity purification from the cerebral cortex. We show that these synaptic complexes contain a variety of neurotransmitter receptors, neural cell-scaffolding and adhesion molecules, but that they are entirely lacking in cell signaling proteins. This fundamental distinction between the functions of type 1 and type 2 synapses in the nervous system has far reaching implications for models of synaptic plasticity, rapid adaptations in neural circuits, and homeostatic mechanisms controlling the balance of excitation and inhibition in the mature brain. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b328677fec973eb1af01ecb2a979257bTest http://edoc.mdc-berlin.de/12440/1/12440oa.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b328677fec973eb1af01ecb2a979257b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |