دورية أكاديمية
Towards the 'baby connectome': mapping the structural connectivity of the newborn brain.
| العنوان: | Towards the 'baby connectome': mapping the structural connectivity of the newborn brain. |
|---|---|
| المؤلفون: | Olga Tymofiyeva, Christopher P Hess, Etay Ziv, Nan Tian, Sonia L Bonifacio, Patrick S McQuillen, Donna M Ferriero, A James Barkovich, Duan Xu |
| المصدر: | PLoS ONE, Vol 7, Iss 2, p e31029 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Defining the structural and functional connectivity of the human brain (the human "connectome") is a basic challenge in neuroscience. Recently, techniques for noninvasively characterizing structural connectivity networks in the adult brain have been developed using diffusion and high-resolution anatomic MRI. The purpose of this study was to establish a framework for assessing structural connectivity in the newborn brain at any stage of development and to show how network properties can be derived in a clinical cohort of six-month old infants sustaining perinatal hypoxic ischemic encephalopathy (HIE). Two different anatomically unconstrained parcellation schemes were proposed and the resulting network metrics were correlated with neurological outcome at 6 months. Elimination and correction of unreliable data, automated parcellation of the cortical surface, and assembling the large-scale baby connectome allowed an unbiased study of the network properties of the newborn brain using graph theoretic analysis. In the application to infants with HIE, a trend to declining brain network integration and segregation was observed with increasing neuromotor deficit scores. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | http://europepmc.org/articles/PMC3274551?pdf=renderTest; https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0031029 |
| الوصول الحر: | https://doaj.org/article/3c2d98c13daa4485b99f3b72d2993a01Test |
| رقم الانضمام: | edsdoj.3c2d98c13daa4485b99f3b72d2993a01 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0031029 |