Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study
| العنوان: | Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study |
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| المؤلفون: | Mavropoulou, Eirini, Mechie, Nicolae-Catalin, Knoop, Richard, Petzold, Golo, Ellenrieder, Volker, Kunsch, Steffen, Pilavakis, Yiannis, Amanzada, Ahmad |
| المصدر: | PLoS ONE, Vol 15, Iss 5, p e0233811 (2020) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Endoscopy, C-reactive proteins, Ulcerative colitis, Inflammatory bowel disease, Corticosteroid therapy, Multivariate analysis, Crohn's disease , Corticosteroid Therapy, Science, Immunology, Surgical and Invasive Medical Procedures, Crohn's Disease, Gastroenterology and Hepatology, Research and Analysis Methods, Biochemistry, Statistics, Nonparametric, Steroid Therapy, Autoimmune Diseases, Immunomodulation, Feces, Mathematical and Statistical Techniques, Drug Therapy, Medicine and Health Sciences, Humans, Ulcerative Colitis, Prospective Studies, Statistical Methods, Interleukin-6, Pharmaceutics, Inflammatory Bowel Disease, Statistics, Biology and Life Sciences, Receptors, Interleukin-2, Middle Aged, Inflammatory Bowel Diseases, Colitis, C-Reactive Protein, ROC Curve, Solubility, Multivariate Analysis, Physical Sciences, Medicine, Female, Clinical Immunology, Clinical Medicine, Leukocyte L1 Antigen Complex, Mathematics, Biomarkers, Research Article |
| الوصف: | Crohn’s disease (CD) and ulcerative colitis (UC) are characterized by overexpression of proinflammatory cytokines. We determined the association of serum levels of interleukin (IL)-6, soluble-IL-2-receptor (sIL-2R) and CRP as well as of faecal calprotectin (FC) values with disease activity in CD and UC patients. This prospective study included 145 CD and 84 UC patients. Serum proinflammatory biomarkers and FC levels were measured and demographic, clinical and endoscopic characteristics were collected. Uni- and multivariate statistical analyses were performed. Serum IL-6 and CRP levels as well as FC values of CD patients were associated with clinical and endoscopic remission. In multivariate analysis serum IL-6 levels remained significantly associated with clinical and endoscopic remission. FC levels were also associated with endoscopic remission in CD patients. CD patients under the threshold levels of 8.5 pg/mL and 5.5 pg/mL for serum IL-6 were in 70% and 66% in clinical and endoscopic remission, respectively. Serum sIL-2R, CRP levels and FC values of UC patients were associated in univariate analysis with clinical and endoscopic remission. In multivariate analysis CRP and FC values were associated with clinical remission and serum sIL-2R as well as FC levels with endoscopic remission. UC patients under the threshold levels of 759 IU/mL and 646 IU/mL for serum sIL-2R were in 76% and 76% in clinical and endoscopic remission, respectively. Beside CRP and FC, serum IL-6 levels in CD patients and sIL-2R levels in UC patients can be a further useful non-invasive biomarker to identify the disease activity status. Open-Access-Publikationsfonds 2020 peerReviewed |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bce7fc8c3c6486e0e844262b9db3e327Test https://doaj.org/article/3866a532ed1548078921eb87b19bb4e9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....bce7fc8c3c6486e0e844262b9db3e327 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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