التفاصيل البيبلوغرافية
| العنوان: |
Bayesian structural time series for biomedical sensor data: A flexible modeling framework for evaluating interventions |
| المؤلفون: |
Liu, Jason, Spakowicz, Daniel J., Ash, Garrett I., Hoyd, Rebecca, Ahluwalia, Rohan, Zhang, Andrew, Lou, Shaoke, Lee, Donghoon, Zhang, Jing, Presley, Carolyn, Greene, Ann, Stults-Kolehmainen, Matthew, Nally, Laura M., Baker, Julien S., Fucito, Lisa M., Weinzimer, Stuart A., Papachristos, Andrew V., Gerstein, Mark |
| المساهمون: |
Papin, Jason A., National Institute on Drug Abuse, U.S. National Library of Medicine, Albert L Williams Award, Office of Academic Affiliations at the United States Veterans Health Administration Fellowship, Robert E. Lee and Clara Guthrie Patterson Trust Mentored Research Award, Bank of America, N.A., Trustee, National Institute of Diabetes and Digestive and Kidney Diseases |
| المصدر: |
PLOS Computational Biology ; volume 17, issue 8, page e1009303 ; ISSN 1553-7358 |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2021 |
| المجموعة: |
PLOS Publications (via CrossRef) |
| الوصف: |
The development of mobile-health technology has the potential to revolutionize personalized medicine. Biomedical sensors (e.g., wearables) can assist with determining treatment plans for individuals, provide quantitative information to healthcare providers, and give objective measurements of health, leading to the goal of precise phenotypic correlates for genotypes. Even though treatments and interventions are becoming more specific and datasets more abundant, measuring the causal impact of health interventions requires careful considerations of complex covariate structures, as well as knowledge of the temporal and spatial properties of the data. Thus, interpreting biomedical sensor data needs to make use of specialized statistical models. Here, we show how the Bayesian structural time series framework, widely used in economics, can be applied to these data. This framework corrects for covariates to provide accurate assessments of the significance of interventions. Furthermore, it allows for a time-dependent confidence interval of impact, which is useful for considering individualized assessments of intervention efficacy. We provide a customized biomedical adaptor tool, MhealthCI, around a specific implementation of the Bayesian structural time series framework that uniformly processes, prepares, and registers diverse biomedical data. We apply the software implementation of MhealthCI to a structured set of examples in biomedicine to showcase the ability of the framework to evaluate interventions with varying levels of data richness and covariate complexity and also compare the performance to other models. Specifically, we show how the framework is able to evaluate an exercise intervention’s effect on stabilizing blood glucose in a diabetes dataset. We also provide a future-anticipating illustration from a behavioral dataset showcasing how the framework integrates complex spatial covariates. Overall, we show the robustness of the Bayesian structural time series framework when applied to biomedical sensor data, ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1371/journal.pcbi.1009303 |
| الإتاحة: |
https://doi.org/10.1371/journal.pcbi.1009303Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F43A3DA4 |
| قاعدة البيانات: |
BASE |
