European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil
| العنوان: | European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil |
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| المؤلفون: | Yara Costa Netto Muniz, Marcelo R. Luizon, Aguinaldo Luiz Simões, Doralina Guimarães Brum, Cristiane Franklin Rocha, Elizabeth Regina Comini-Frota, Celso T. Mendes-Junior, Enedina Maria Lobato de Oliveira, Marco Aurélio Lana-Peixoto, Eduardo Antônio Donadi, Damacio Ramón Kaimen-Maciel, Roberta Martins da Silva Costa, Denis Bernardi Bichuetti, Alberto Alan Gabbai, Cláudia Emília Vieira Wiezel, Denise Sisterolli Diniz, Amilton Antunes Barreira, Maria Lucia Brito, Antonio Carlos dos Santos |
| المساهمون: | Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp), Universidade Federal de Minas Gerais (UFMG), Hospital da Restauração, Universidade Federal de São Paulo (UNIFESP), Universidade Federal de Goiás (UFG), Universidade Estadual de Londrina (UEL) |
| المصدر: | PLoS ONE, Vol 8, Iss 3, p e58925 (2013) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Pediatrics, Epidemiology, genotype, Prevalence, myelooptic neuropathy, multiple sclerosis, population genetic parameters, Gene Frequency, single nucleotide polymorphism, Genotype, Ethnicity, indel mutation, African American, European American, Genetics, Multidisciplinary, adult, Neuromyelitis Optica, Middle Aged, female, Neurology, Genetic Epidemiology, American Indian, Medicine, Female, Brazil, gene insertion, Research Article, Adult, Genetic Markers, medicine.medical_specialty, ESCLEROSE MÚLTIPLA (GENÉTICA), Multiple Sclerosis, bone marrow, Genetic genealogy, Science, Single-nucleotide polymorphism, Ancestry-informative marker, ancestry informative marker, gene frequency, Biology, Autoimmune Diseases, Young Adult, male, geographic distribution, medicine, Humans, controlled study, human, genealogy, Allele frequency, Genetic Association Studies, Neuromyelitis optica, Population Biology, Multiple sclerosis, high risk population, Human Genetics, medicine.disease, Demyelinating Disorders, major clinical study, human tissue, Biomarker Epidemiology, plesiomorphy, Clinical Immunology |
| الوصف: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:28:42Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:22Z : No. of bitstreams: 1 2-s2.0-84875195830.pdf: 324522 bytes, checksum: 267b0650456f6d415bbc8ed2ec7e9c57 (MD5) Made available in DSpace on 2014-05-27T11:28:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-03-20 Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP). Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population. Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil. © 2013 Brum et al. Dept. de Neurociencias e Ciencias do Comportamento da Faculdade de Medicina de Ribeirao Preto Universidade de São Paulo, USP, Ribeirão Preto, São Paulo Departamento de Neurologia, Psicologia e Psiquiatria Faculdade de Medicina de Botucatu Universidade Estadual Paulista -UNESP, Botucatu, São Paulo Departamento de Genética da Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, USP, Ribeirão Preto, São Paulo Departamento de Oftalmologia e Otorrinolaringologia da Faculdade de Medicina Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais Secretaria de Saúde do Estado de Pernambuco Hospital da Restauração, Recife, Pernambuco Departamento de Neurologia e Neurocirurgia Universidade Federal de São Paulo, São Paulo Departamento de Clínica Médica Faculdade de Medicina Universidade Federal de Goiás, Goiânia, Goiás Departamento de Clínica Médica Centro de Ciências da Saúde Universidade Estadual de Londrina, Londrina, Paraná Departamento de Neurologia da Faculdade de Medicina Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais Departamento de Clínica Médica Divisão de Imunologia Clínica da Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo-USP, Ribeirão Preto, São Paulo Departamento de Oftalmologia e Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Ribeirão Preto, da Universidade de São Paulo, USP, Ribeirão Preto, São Paulo Departamento de Química Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, São Paulo Departamento de Neurologia, Psicologia e Psiquiatria Faculdade de Medicina de Botucatu Universidade Estadual Paulista -UNESP, Botucatu, São Paulo |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caea26a2b9351e5163b741b35f91cdeTest https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527051/?tool=EBITest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1caea26a2b9351e5163b741b35f91cde |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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