The period effect in the prevalence of proliferative diabetic retinopathy, gross proteinuria, and peripheral neuropathy in type 1 diabetes: A longitudinal cohort study
| العنوان: | The period effect in the prevalence of proliferative diabetic retinopathy, gross proteinuria, and peripheral neuropathy in type 1 diabetes: A longitudinal cohort study |
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| المؤلفون: | Kristine E. Lee, Barbara E.K. Klein, Kayla L. Horak, Ronald Klein, Christine A Kiire |
| المصدر: | PLoS ONE, Vol 12, Iss 3, p e0174979 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, lcsh:Medicine, Blood Pressure, Pathology and Laboratory Medicine, Biochemistry, Vascular Medicine, Cohort Studies, 0302 clinical medicine, Endocrinology, Risk Factors, Prevalence, Medicine and Health Sciences, Diabetes diagnosis and management, 030212 general & internal medicine, Longitudinal Studies, lcsh:Science, Multidisciplinary, Proteinuria, Confounding, Peripheral Nervous System Diseases, Diabetic retinopathy, Neurology, Cohort, Retinal Disorders, Female, medicine.symptom, Cohort study, Research Article, Adult, medicine.medical_specialty, HbA1c, Endocrine Disorders, 030209 endocrinology & metabolism, Surgical and Invasive Medical Procedures, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Humans, Hemoglobin, Retinopathy, Peripheral Neuropathy, Type 1 diabetes, Transplantation, Diabetic Retinopathy, Biology and life sciences, business.industry, lcsh:R, Proteins, Organ Transplantation, medicine.disease, Neuropathy, Ophthalmology, Peripheral neuropathy, Diabetes Mellitus, Type 1, Logistic Models, Metabolic Disorders, lcsh:Q, business |
| الوصف: | Aims To investigate whether, for a specific duration of type 1 diabetes, there is a significant change in the prevalence of proliferative diabetic retinopathy, gross proteinuria and peripheral neuropathy in those more recently diagnosed with diabetes (a period effect), in the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Where present, to determine how common risk factors for diabetic complications might be associated with it, and what might be driving it. Materials and methods Longitudinal cohort study with seven examination phases between 1980 and 2014. Multivariate logistic regression models and ordinal parameterization were used to test for and evaluate any period effect. Results There is a period effect in the prevalence of gross proteinuria and peripheral neuropathy (decreasing), as seen with proliferative diabetic retinopathy (p < 0.001). Adjusting for changing levels of common risk factors attenuates the period effect, particularly for proliferative diabetic retinopathy. For gross proteinuria and peripheral neuropathy, however there is a persistent period effect in spite of adjusting for the major risk factors. Conclusions There are period effects in the prevalence of proliferative diabetic retinopathy, gross proteinuria and peripheral neuropathy that cannot be fully explained by changes in common risk factors for complications of type 1 diabetes in this cohort. The role of other potential confounders warrants further exploration. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d35b35bdb3ee9e4d150a65b35a58a2Test http://europepmc.org/articles/PMC5376304?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....80d35b35bdb3ee9e4d150a65b35a58a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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