Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Groningen Research Institute for Asthma and COPD (GRIAC), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Medicinal Chemistry and Bioanalysis (MCB), Molecular and Computational Toxicology, AIMMS
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PLoS ONE, Vol 7, Iss 11, p e49524 (2012) PLoS One, 7, 11 PLoS ONE, 7(11):e49524. PUBLIC LIBRARY SCIENCE van Swelm, R, Laarakkers, C M, van der Kuur, E C, Morava-Kozicz, E, Wevers, R A, Augustijn, K D, Touw, D J, Sandel, M H, Masereeuw, R & Russel, F G M 2012, ' Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice ', PLoS ONE, vol. 7, no. 11, e49524 . https://doi.org/10.1371/journal.pone.0049524Test PLoS One, 7 PLoS ONE, 7(11):e49524. Public Library of Science PLoS ONE
Contains fulltext : 108207.pdf (Publisher’s version ) (Open Access) Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of >/=275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p
