BOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation
| العنوان: | BOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation |
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| المؤلفون: | Iris Y. Zhou, Ed X. Wu, Matthew M. Cheung, Condon Lau, Kevin C. Chan |
| المصدر: | PLoS ONE, Vol 6, Iss 4, p e18914 (2011) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Monocrystalline iron oxide nanoparticle, Time Factors, genetic structures, Visual System, Photic Stimulation, Functional magnetic resonance imaging, lcsh:Medicine, Stimulation, Visual system, Ferric Compounds, Brain mapping, Diagnostic Radiology, Rats, Sprague-Dawley, Brain cortex, Superior Colliculi, lcsh:Science, Neurons, Brain Mapping, Multidisciplinary, Brain blood vessel, medicine.diagnostic_test, fMRI, Geniculate Bodies, Animal Models, Anatomy, Magnetic Resonance Imaging, Sensory Systems, Medicine, Radiology, psychological phenomena and processes, Research Article, Neuroimaging, Lateral geniculate nucleus, Model Organisms, medicine, Animals, Visual Pathways, Biology, Vision, Ocular, Superior colliculus, lcsh:R, Rats, Oxygen, Blood oxygenation, nervous system, Rat, lcsh:Q, Neuroscience |
| الوصف: | Background: The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding of vision was obtained using invasive and small field of view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent (BOLD) fMRI to measure the SC and LGN's response temporal dynamics following short duration (1 s) visual stimulation. Methodology/Principal Findings: Experiments are performed at 7 tesla on Sprague Dawley rats stimulated in one eye with flashing light. Gradient-echo and spin-echo sequences are used to provide complementary information. An anatomical image is acquired from one rat after injection of monocrystalline iron oxide nanoparticles (MION), a blood vessel contrast agent. BOLD responses are concentrated in the contralateral SC and LGN. The SC BOLD signal measured with gradient-echo rises to 50% of maximum amplitude (PEAK) 0.2±0.2 s before the LGN signal (p published_or_final_version |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0196aa416c141b8b4b84f5bb80a9842Test http://europepmc.org/articles/PMC3084720?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0196aa416c141b8b4b84f5bb80a9842 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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